Process for the production of particles
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Abstract
A process for the production of particles comprises the steps of formation of a solution of a desired substance in a suitable solvent; ii)generation of an aerosol from the solution of said substance; iii) collection of the aerosol droplets in a vessel containing a non-solvent of said substance; and iv) application of ultrasound to the droplets dispersed in the non-solvent to effect crystallisation of said substance. The particles produced find application in for example pharmaceutical and agrochemical formulations, especially in inhalation formulations.
26 Citations
44 Claims
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1-20. -20. (canceled)
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21. A method for producing crystalline particles comprising the steps of:
- i) forming a solution of a desired substance in a suitable solvent;
ii) generating aerosol droplets from the solution of said substance;
iii) collecting the aerosol droplets in a vessel containing a non-solvent of said substance; and
iv) applying ultrasonic energy to the droplets dispersed in the non-solvent to effect crystallisation of said substance, thereby producing crystalline particles. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
- i) forming a solution of a desired substance in a suitable solvent;
- 36. Crystalline particles suitable for use in a formulation selected from the group consisting of a pharmaceutical formulation and an agrochemical formulation, wherein the particles are substantially spherical.
- 39. An apparatus adapted for producing crystalline particles comprising i) an aerosol generator, ii) a collection vessel for collecting aerosol droplets, and iii) a means for applying ultrasonic energy to the collected aerosol droplets and wherein the crystalline particles so produced are substantially spherical.
Specification