Methods for drug discovery, disease treatment, and diagnosis using metabolomics
First Claim
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1. A method for identifying small molecules affected by an agent comprising:
- obtaining a small molecule profile of said cellular compartment treated with an agent, and comparing said small molecule profile to a standard small molecule profile;
thereby, identifying the compounds affected by said agent in said cellular compartment.
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Abstract
The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.
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21 Claims
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1. A method for identifying small molecules affected by an agent comprising:
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obtaining a small molecule profile of said cellular compartment treated with an agent, and comparing said small molecule profile to a standard small molecule profile;
thereby, identifying the compounds affected by said agent in said cellular compartment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for metabolomically monitoring a therapeutic agent, comprising:
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obtaining a small molecule profile from a subject being treated with a therapeutic agent; and
monitoring changes in the small molecule profile of the subject. - View Dependent Claims (12, 13, 14)
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15. A method for monitoring the effectiveness of treatment of a subject with an agent, comprising:
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administering an agent to a subject;
obtaining a post-administration sample from said subject;
detecting a small molecule profile of the post-administration sample;
comparing the small molecule profile of the post-administration sample with a standard profile; and
altering the administration of the agent to the subject accordingly. - View Dependent Claims (16, 17, 18, 19, 20)
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21-45. -45. (canceled)
Specification