Article tissue systems and uses thereof
First Claim
1. An artificial tissue system, comprising:
- (a) a matrix configured for biological contact with an implantable device, and (b) a plurality of cells supported by said matrix, said cells promoting a biological interaction between said implantable device and a biological system.
3 Assignments
0 Petitions
Accused Products
Abstract
An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site of implantation. The ATS includes cells, such as naturally occurring, engineered, and/or artificial cells; matrices such as natural, engineered, artificial and/or hybrid matrices; tissue response modifiers (TRM); and/or cell response modifiers (CRM). The specific composition of the ATS is based on the nature of the tissue in which ATS-device combination is implanted and the nature of the implant device, as well as the required function and lifespan of the implanted device. Additionally, the ATS, as well as ATS-device combinations can be utilized in vitro to aid in the design of improved ATS, devices and ATS-device combinations for in vivo uses.
68 Citations
63 Claims
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1. An artificial tissue system, comprising:
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(a) a matrix configured for biological contact with an implantable device, and (b) a plurality of cells supported by said matrix, said cells promoting a biological interaction between said implantable device and a biological system. - View Dependent Claims (2, 3, 4, 9, 14, 15, 16, 19, 20, 25, 27, 36, 50, 51)
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5-8. -8. (canceled)
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10-13. -13. (canceled)
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17-18. -18. (canceled)
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21-24. -24. (canceled)
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26. (canceled)
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28. An implant system comprising:
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(a) an implantable device, (b) a matrix in biological contact with said implantable device, and (c) a plurality of cells supported by said matrix, said cells promoting a biological interaction between said implantable device and a biological system. - View Dependent Claims (52)
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29. A method of implanting a device in a biological system, comprising the steps of:
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(a) obtaining said device, (b) obtaining a matrix, (c) placing said device in biological contact with said matrix, (d) inserting cells into said matrix, said cells being capable of promoting a biological interaction between said implantable device and said biological system, and (e) implanting said matrix into said biological system. - View Dependent Claims (32, 35, 53, 57)
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30-31. -31. (canceled)
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33-34. -34. (canceled)
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37. An artificial implant system in biological contact with a biological system comprising:
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(a) a cellular component, said cellular component includes at least one cellular community which induces a biological response in the biological system;
(b) a matrix material, said matrix material being associated with a portion of the cellular community; and
(c) an implant device having a biological interface wherein said biological interface is associated with the matrix material and the biological system. - View Dependent Claims (38, 39, 54, 59)
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40-49. -49. (canceled)
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55-56. -56. (canceled)
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58. (canceled)
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60. An implant system comprising:
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(a) an implantable device comprising a sensor, and (b) a matrix comprising a gel in biological contact with said implantable device, said matrix promoting biocompatibility of said implantable device and a biological system.
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61. A method of improving the biocompatibility of a sensor with a tissue system comprising placing a matrix comprising a gel between the sensor and the tissue system.
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62. A method of implanting a device in a biological system, comprising:
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(a) obtaining an implantable device, (b) forming an implantation pocket in the biological system by injecting a biocompatible material, and (b) implanting said implantable device in said implantation pocket.
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63-65. -65. (canceled)
Specification