System and method for determining a treatment dose for a patient

• US 20070083090A1
• Filed: 12/21/2005
• Published: 04/12/2007
• Est. Priority Date: 10/06/2005
• Status: Active Grant

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Rule, Peter, Braig, James, King, Richard, Sterling, Bernhard
• Granted Patent: US 7,785,258 B2
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150862 intermediate range, e.g. within room or building
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2230/20 Blood composition characteristics
• CPC Class Codes: A61M 5/14212 Pumping with an aspiration and an expulsion action
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/35 using infrared light G01N21/39 takes precedence
• CPC Class Codes: G01N 2201/1293 resolving multicomponent spectra
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection

Abstract

In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.

Claims

1. A method of maintaining health of a patient using an analyte detection system coupled to said patient such that a bodily fluid of said patient is accessible to said analyte detection system, said method comprising:

automatically initiating and conducting a measurement of an analyte in said bodily fluid using said analyte detection system; and

determining a treatment dose for said patient based on said measurement using said analyte detection system.

2. The method of claim 1, wherein said analyte is glucose.

3. The method of claim 2, wherein said bodily fluid is blood.

4. The method of claim 2, wherein said bodily fluid is plasma.

5. The method of claim 1, further comprising drawing a portion of said bodily fluid from said patient through a conduit.

6. The method of claim 5, wherein said conduit provides fluid communication between said patient and said analyte detection system.

7. The method of claim 5, wherein conducting said measurement comprises analyzing said portion of said bodily fluid from said patient using said analyte detection system.

8. The method of claim 1, wherein said treatment dose comprises a dose of insulin.

9. The method of claim 1, wherein said treatment dose comprises a dose of food, drink, or parenteral nutrition.

10. The method of claim 1, wherein conducting said measurement comprises conducting an optical measurement.

11. The method of claim 10, wherein said optical measurement is a spectroscopic measurement.

12. The method of claim 1, wherein conducting said measurement comprises conducting an optical measurement and an electrochemical measurement.

13. The method of claim 1, further comprising outputting information regarding said treatment dose.

14. The method of claim 13, wherein outputting information comprises displaying said information on a screen.

15. The method of claim 13, wherein outputting information comprises making said treatment dose information accessible by a dose administrator.

16. The method of claim 15, wherein said dose administrator is a medical practitioner.

17. The method of claim 15, wherein said dose administrator comprises an infusion pump.

18. The method of claim 15, wherein said dose administrator comprises an insulin pump.

19. The method of claim 15, further comprising delivering said treatment dose to said patient via said dose administrator.

20. The method of claim 19, wherein said dose administrator comprises an infusion pump.

21. The method of claim 19, wherein said dose administrator comprises an insulin pump.

22. The method of claim 1, wherein said treatment dose is determined based on said measurement and on additional information.

23. The method of claim 22, further comprising determining a rate of change of said analyte in said bodily fluid, wherein said additional information comprises said rate of change.

24. The method of claim 22, further comprising determining a response of said patient to one or more previously administered treatment doses, wherein said additional information comprises said response.

25. The method of claim 22, wherein said additional information comprises one or more measurements of one or more additional analytes.

26. The method of claim 25, wherein said one or more additional analytes comprises lactate, carbon dioxide, hematocrit, BUN, creatinine, PO2, PCO2, or a medicament.

27. The method of claim 22, further comprising conducting an additional measurement of an additional analyte using said analyte detection system, wherein said additional information comprises said additional measurement.

28. The method of claim 27, wherein said additional analyte is lactate, carbon dioxide, hematocrit, BUN, creatinine, PO2, PCO2, or a drug taken by or administered to said patient.

29. The method of claim 22, wherein said additional information comprises information obtained from a data network connected to said analyte detection system.

30. The method of claim 29, wherein said data network comprises a hospital information system network.

31. The method of claim 29, wherein said additional information comprises a patient electronic medical record stored on said data network.

32. The method of claim 22, wherein said additional information comprises a treatment dosing protocol.

33. A method of monitoring status of a patient using an analyte detection system associated with a patient such that said analyte detection system can access a bodily fluid of said patient, said method comprising:

obtaining a measurement of an analyte in said bodily fluid using said analyte detection system;

obtaining additional information from a data network accessible to said analyte detection system;

determining a treatment dose for said patient using said analyte detection system and based on said measurement and on said additional information.

34. The method of claim 33, wherein said additional information comprises one or more previously administered treatment doses.

35. The method of claim 33, wherein said additional information comprises a response by said patient to one or more previously administered treatment doses.

36. The method of claim 33, wherein said additional information comprises a medication being administered to said patient.

37. The method of claim 33, further comprising communicating said treatment dose to a dose administrator.

38. The method of claim 33, wherein said obtaining of said measurement is initiated automatically by said analyte detection system.

39. The method of claim 33, further comprising prompting for confirmation that said treatment dose has been taken by or administered to said patient, said prompting performed using said analyte detection system.

40. The method of claim 33, further comprising recording an administration of said treatment dose to said patient in a patient electronic medical record located on said network.

41. The method of claim 33, further comprising storing one or more measurements of said analyte.

42. The method of claim 41, wherein said additional data comprises said one or more stored measurements.

43. The method of claim 41, further comprising computing a rate of change of a level of said analyte based on said one or more stored measurements.

44. The method of claim 43, wherein said additional data comprises said rate of change.

45. An analyte detection system for measuring an analyte in a bodily fluid of a patient, said system comprising:

a sensor in fluid communication with said bodily fluid, said sensor configured to provide information relating to said analyte in a sample of said bodily fluid;

a processor; and

stored program instructions executable by said processor such that said analyte detection system;

automatically initiates and conducts a measurement of said sample with said sensor; and

determines a treatment dose for said patient based on said measurement.

46. The analyte detection system of claim 45, wherein said stored program instructions are executable by said processor such that said analyte detection system outputs information regarding said treatment dose.

47. The analyte detection system of claim 45, wherein said stored program instructions are executable by said processor such that said analyte detection system determines said treatment dose based on said measurement and on information additional to said measurement.

48. An analyte detection system for use with a data network, said system comprising:

a sensor configured to provide information relating to a measurement of an analyte in a bodily fluid of a patient;

a network connection for providing connectivity to said data network;

a processor; and

stored program instructions executable by said processor such that said analyte detection system;

conducts said measurement;

accesses additional information stored on said data network; and

determines a treatment dose for said patient based on said measurement and said additional information.

49. The analyte detection system of claim 48, wherein said stored program instructions are executable by said processor such that said analyte detection system delivers information regarding said treatment dose to a dose administrator.