METHOD OF TREATING VASCULAR DISEASE AT A BIFURCATED VESSEL USING A COATED BALLOON

• US 20070088255A1
• Filed: 10/10/2006
• Published: 04/19/2007
• Est. Priority Date: 03/19/2004
• Status: Abandoned Application

• Current Assignee: John Toner, Keith R. Cromack, Randolf Oepen, Sandra Burke
• Original Assignee: John Toner, Keith R. Cromack, Randolf Oepen, Sandra Burke
• Inventors: Cromack, Keith, Toner, John, Oepen, Randolf, Burke, Sandra
• Application Number:
  US11/539,944
• Publication Number:
  US 20070088255A1
• Time in Patent Office: Days
• US Class Current: 604/96.10
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2310/0097 Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Disclosed is a method for delivery of at least one therapeutic agent from an angioplasty balloon for treating vascular disease at a bifurcated vessel. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to a method of loading multiple beneficial agents onto the balloon surfaces

Claims

1. A method for treating vascular disease in a bifurcated vessel, comprising the steps of;

deploying a balloon within a first branch of a bifurcated vessel, wherein the balloon includes a surface that is at least partially coated with at least one beneficial agent; and

delivering a therapeutically effective amount of the at least one beneficial agent to the first branch of the bifurcated vessel.

2. A method according to claim 1, further comprising the step of:

deploying a first stent device within the first branch of the bifurcated vessel.

4. A method according to claim 1, further comprising the step of:

deploying a first stent device within a second branch of the bifurcated vessel, and

deploying a second stent device within the first branch of the bifurcated vessel.

5. A method according to claim 2, wherein the stent device is deployed prior to the deployment of the balloon with a surface that is at least partially coated with a beneficial agent.

6. A method according to claim 4, wherein the stent devices are deployed prior to the deployment of the balloon with a surface that is at least partially coated with a beneficial agent.

7. A method according to claim 1, wherein the at least one beneficial agent is chosen from the group comprising of Zotorolimus (ABT578), rapamycin, or rapamycin analogies, dexamethasone, estradiol, paclitaxel, taxanes, or other taxane derivatives.

9. A method according to claim 1, further comprising the step of delivering a therapeutically effective amount of a second beneficial agent to the first branch of the bifurcated vessel.

10. A method according to claim 9, wherein the second beneficial agent is disposed upon the at least one beneficial agent.

11. A method according to claim 9, wherein the at least one beneficial agent and the second beneficial agent are disposed upon the surface of the balloon having a pattern.

3. A method according to claim T, further comprising the step of:

deploying a second stent device within a second branch of the bifurcated vessel.

8. A method according to claim 3, wherein the stent device is deployed prior to the deployment of the balloon with a surface that is at least partially coated with a beneficial agent.

12. A method for treating vascular disease in a bifurcated vessel, comprising the steps of:

deploying a first stent device within the first branch of the bifurcated vessel;

deploying a second stent device within a second branch of the bifurcated vessel;

deploying a balloon within a first branch of a bifurcated vessel, wherein the balloon includes a surface that is at least partially coated with at least one beneficial agent; and

delivering a therapeutically effective amount of the at least one beneficial agent to the first branch of the bifurcated vessel.

13. A method according to claim 12, wherein either stent device is deployed prior to the deployment of the balloon.

14. A method according to claim 12, wherein the at least one beneficial agent is chosen from the group comprising of Zotarolimus (ABT578), rapamycin, or rapamycin analogies, dexamethasone, estradiol, paclitaxel, taxanes, or other taxane derivatives.