Substance delivery system

• US 20070106270A1
• Filed: 01/18/2006
• Published: 05/10/2007
• Est. Priority Date: 11/09/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Langer, Robert, Jung, Edward, Hood, Leroy, Tegreene, Clarence, Wood, Lowell, Ishikawa, Muriel, Wood, Victoria
• Granted Patent: US 8,882,747 B2
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

Claims

1. A delivery system, comprising:

a delivery device including;

a fluid-containing structure having at least one outlet through which fluid may exit the fluid-containing structure;

a delivery fluid contained within the fluid-containing structure;

a primary material contained within the fluid-containing structure and having a controllable effective concentration in the delivery fluid; and

at least one electromagnetically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an incident electromagnetic control signal to modify the effective concentration of the primary material in the delivery fluid, the effective concentration being the concentration of the first active form in the delivery fluid; and

a remote controller including;

an electromagnetic signal generator capable of producing an electromagnetic control signal sufficient to activate the electromagnetically responsive control element of the delivery device located in an environment to change the effective concentration of the primary material in the delivery fluid within the fluid-containing structure of the delivery device; and

an electromagnetic signal transmitter capable of wirelessly transmitting the electromagnetic control signal to the electromagnetically responsive control element of the delivery device in the environment

2. The delivery system of claim 1, wherein the remote controller includes at least one of hardware, firmware, or software configured to control generation of the electromagnetic control signal.

3. The delivery system of claim 1, wherein the delivery device includes an RFID, and wherein the remote controller includes an RF interrogation signal generator for generating an RF interrogation signal tuned to the RFID.

20. The delivery system of claim 1, wherein the delivery device includes a plurality of electromagnetically responsive control elements.

23. The delivery system of claim 1, wherein the remote controller is configured to generate and transmit an electromagnetic control signal having at least one of frequency and orientation that are selectively receivable by the at least one magnetically responsive control element.

24. The delivery system of claim 1, wherein the remote controller includes at least one of hardware, software, or firmware configured to perform encryption of electromagnetic control signal to produce an encrypted electromagnetic control signal.

57. The delivery system of claim 1, wherein the delivery device includes a body structure adapted for positioning in an environment selected from a body of an organism, a body of water, a contained fluid volume, an industrial fluid volume, an agricultural fluid volume, a swimming pool, an aquarium, a drinking water supply, a potable water supply, and an HVAC system cooling water supply.

58. The delivery system of claim 1, wherein the electromagnetically responsive control element includes a magnetically or electrically active material including at least one permanently magnetizable material, ferromagnetic material, ferrimagnetic material, ferrous material, ferric material, dielectric material, ferroelectric material, piezoelectric material, diamagnetic material, paramagnetic material, metallic material, orantiferromagnetic material, polymer, ceramic, metal, shape memory material, or combination of a polymer and a magnetically or electrically active component.

59. The delivery system of claim 1, including a remote controller configured to generate a static or quasi-static electrical field control signal, a static or quasi-static magnetic field control signal, a radio-frequency electromagnetic control signal, a microwave electromagnetic control signal, an infrared electromagnetic control signal, a millimeter wave electromagnetic control signal, an optical electromagnetic control signal, or an ultraviolet electromagnetic control signal sufficient to activate the electromagnetically responsive control element to control the effective concentration of the primary material in the delivery fluid.

60. The delivery system of claim 1, including a plurality of delivery devices, and wherein the remote controller is configured to produce a rotating electromagnetic signal, the rotating electromagnetic signal capable of activating two or more of the plurality of delivery devices independently as a function of the orientation of the rotating electromagnetic signal.

61. The delivery system of claim 1, including a plurality of delivery devices and a plurality of remote controllers, wherein each delivery device is controlled by a separate remote controller, or by one or more control signals produced in a distributed fashion by two or more of the plurality of remote controllers.

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25. A method of delivering a material including:

pumping a delivery fluid containing a primary material from a delivery reservoir of a delivery device to a downstream location at a first pumping rate; and

controlling the effective concentration of the primary material in the delivery fluid in response to a remotely transmitted electromagnetic control signal.

62. The method of claim 25, wherein the first pumping rate is a constant pumping rate, and wherein the method includes varying the rate of delivery of the primary material to the downstream location by varying the effective concentration of the primary material in the delivery fluid in response to the remotely transmitted electromagnetic control signal.

63. The method of claim 25, wherein the first pumping rate is a time-varying pumping rate, and wherein the method includes controlling the rate of delivery of the primary material to the downstream location by controlling both the effective concentration of the primary material in the delivery fluid and the pumping rate.

64. The method of claim 25, including controlling at least one of the first pumping rate or the effective concentration of the primary material in the delivery fluid through activation of an electromagnetically responsive control element in the delivery device by the remotely transmitted electromagnetic control signal.

65. The method of claim 64, wherein activation of the electromagnetically responsive control element includes at least one of heating, cooling, change in at least one dimension, change in orientation, or change in conformation of the electromagnetically responsive control element.

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37. A method of delivering a material, including:

receiving a first electromagnetic control signal with a first electromagnetically responsive control element in a delivery device, the delivery device including a fluid-containing structure containing a delivery fluid and a primary material distributed between a first active form carried in the delivery fluid and a second form, the primary material having a first effective concentration in the delivery fluid equal to the concentration of the first active form in the delivery fluid;

responsive to receipt of the first electromagnetic control signal by the first electromagnetically responsive control element, modifying the distribution of the primary material between the first active form and the second form, the primary material having a second effective concentration in the delivery fluid following the modification of the distribution of the primary material between the first active form and the second form; and

pumping the delivery fluid containing the primary material at the second effective concentration from the fluid-containing structure of the delivery device to a downstream location.

42. The method of claim 37, including filtering the second form of the primary material from the delivery fluid prior to pumping the delivery fluid containing the primary material at the second effective concentration from the fluid-containing structure of the delivery device to a downstream location.

45. The method of claim 37, including modifying the rate of pumping of the delivery fluid to the downstream location responsive to receipt of a second electromagnetic control signal by a second electromagnetically responsive control element.

46. The method of claim 45, wherein the first electromagnetic control signal and the second electromagnetic control signal are the same electromagnetic control signal.

47. The method of claim 45, wherein the first electromagnetic control signal is different than the second electromagnetic control signal.

66. The method of claim 37, wherein the primary material has a different stability, immunogenicity, reactivity, or activity in the first active form than in the second form.

67. The method of claim 37, wherein the first effective concentration is different than the second effective concentration.

68. The method of claim 45, wherein the first electromagnetically responsive control element and the second electromagnetically responsive control element are the same electromagnetically responsive control element, different control elements of the same type, or different control elements of different types.

69. The method of claim 37, including modifying the distribution of primary material in response to receipt of the first electromagnetic control signal by modifying a pressure within the fluid containing structure;

modifying a volume of the fluid containing structure;

producing vibration within the fluid containing structure;

primary material in response to receipt of the first electromagnetic control signal by producing fluid mixing within the fluid containing structure;

or modifying a number of available interaction sites within the fluid containing structure, the available interaction sites capable of interacting with the primary material to produce the second form of the primary material.

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