Selectively exposable miniature probes with integrated sensor arrays for continuous in vivo diagnostics
First Claim
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1. A medical detecting device comprising:
- a plate having at least one microprotrusion fixed attached and extending from the plate; and
at least one agent detecting sensor on the at least one microprotrusion, wherein said at least one agent detecting sensor is covered with a biocompatible protective coating which is selectively removed prior to detecting an agent, and said at least one microprotrusion having a length which locates the at least one agent detecting sensor below the outermost layer of a body surface and in contact with a body fluid.
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Abstract
A medical detecting device including at least one miniature probe/lance (hereinafter microprotrusion) containing an integrated sensor which is covered with a protective coating to shield the sensor from fouling and other interactions with a host prior to its desired use is provided. In accordance with the present invention, the protective coating is selectively removed from the sensor prior to using the same. The present invention also provides a method for detecting a selected agent using the medical detecting device of the present invention.
12 Citations
24 Claims
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1. A medical detecting device comprising:
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a plate having at least one microprotrusion fixed attached and extending from the plate; and
at least one agent detecting sensor on the at least one microprotrusion, wherein said at least one agent detecting sensor is covered with a biocompatible protective coating which is selectively removed prior to detecting an agent, and said at least one microprotrusion having a length which locates the at least one agent detecting sensor below the outermost layer of a body surface and in contact with a body fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of detecting an agent comprising:
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providing a medical detecting device that includes a plate having at least one microprotrusion fixedly attached and extending from the plate; and
at least one agent detecting sensor on the at least one microprotrusion, wherein said at least one agent detecting sensor is covered with a biocompatible protective coating, and said at least one microprotrusion having a length which locates the at least one agent detecting sensor below the outermost layer of a body surface and in contact with a body fluid;
selectively removing the biocompatible protective coating from the at least one agent detecting sensor to expose the sensor; and
detecting an agent. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of detecting glucose comprising:
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providing a medical detecting device that includes a plate having at least one microprotrusion fixedly attached and extending from the plate; and
at least one electrochemical sensor on the at least one microprotrusion, wherein said at least one electrochemical sensor is covered with a biocompatible protective coating, and said at least one microprotrusion having a length which locates the at least one electrochemical sensor below the outermost layer of skin and in contact with a interstitial fluid;
selectively removing the biocompatible protective coating from the at least one electrochemical sensor to expose the sensor;
detecting glucose, wherein said steps of selectively removing and detecting are repeated numerous times to provide prolonged periodic or continuous detection of glucose. - View Dependent Claims (24)
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Specification