BIOSENSOR WITH ANTIMICROBIAL AGENT

• US 20070135699A1
• Filed: 12/12/2006
• Published: 06/14/2007
• Est. Priority Date: 12/12/2005
• Status: Abandoned Application

• Current Assignee: Isense Corporation
• Original Assignee: Isense Corporation
• Inventors: Bruce, Robert, Neinast, Mark, Ward, W., Sass, Richard
• Application Number:
  US11/609,768
• Publication Number:
  US 20070135699A1
• Time in Patent Office: Days
• US Class Current: 600/373
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 2562/225 Connectors or couplings
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/6833 Adhesive patches

Abstract

Embodiments of the present invention provide methods, apparatuses, and systems for sensing analyte with devices having antimicrobial properties. Embodiments of the present invention provide specialized coatings or specialized materials that reduce the risk of tissue infection around biosensors that reside fully or partially within subcutaneous tissue or within a blood vessel.

Claims

1. A biosensor, comprising:

an elongated indicating electrode circumferentially surrounded along at least a portion thereof by an insulating layer; and

a silver/silver chloride reference electrode circumferentially surrounding at least a portion of said insulating layer, wherein said silver/silver chloride reference electrode is adapted to, when in use, extend from a location above a skin surface to a location beneath the skin surface.

2. The biosensor of claim 1, wherein said elongated indicating electrode is a flexible wire-type electrode.

3. The biosensor of claim 1, wherein said elongated indicating electrode is a hollow tube constructed of metal, polymer, or glass.

4. The biosensor of claim 1, wherein said silver/silver chloride reference electrode is further coated at least partially by a further antimicrobial agent.

5. The biosensor of claim 4, wherein said antimicrobial agent circumferentially surrounds at least a portion of said silver/silver chloride reference electrode.

6. A biosensor, comprising:

an elongated indicating electrode circumferentially surrounded along at least a portion thereof by an insulating layer; and

an antimicrobial reference electrode circumferentially surrounding at least a portion of said insulating layer, wherein said antimicrobial reference electrode is adapted to, when in use, extend from a location above a skin surface to a location beneath the skin surface.

7. The biosensor of claim 6, wherein an antimicrobial property of said antimicrobial reference electrode is imparted by selecting a material for said antimicrobial reference electrode from silver, gold, platinum, palladium, iridium, zinc, copper, tin, antimony, bismuth, or mixtures thereof.

8. The biosensor of claim 6, wherein an antimicrobial property of said antimicrobial reference electrode is imparted by coating a reference electrode at least partially with an antimicrobial agent to form said antimicrobial reference electrode.

9. The biosensor of claim 8, wherein said antimicrobial agent circumferentially surrounds at least a portion of said reference electrode.

10. The biosensor of claim 6, wherein said elongated indicating electrode is a flexible wire-type electrode.

11. The biosensor of claim 6, wherein said elongated indicating electrode is a hollow tube constructed of metal, polymer, or glass.

12. An analyte sensing system, comprising:

a biosensor having an elongated indicating electrode circumferentially surrounded along at least a portion thereof by an insulating layer, and an antimicrobial reference electrode circumferentially surrounding at least a portion of said insulating layer, wherein said antimicrobial reference electrode is adapted to, when in use, extend from a location above a skin surface to a location beneath the skin surface;

an on-skin unit configured to electrically couple to said biosensor to receive a signal from said biosensor when in use.

13. The analyte sensing system of claim 12, further comprising a patch wherein said on-skin unit is further configured to couple to said patch and said patch is configured to be secured to skin when in use.

14. The analyte sensing system of claim 13, wherein said patch further comprises adhesive on one or both primary surfaces to secure said patch to said on skin-unit and/or to skin when in use.

15. The analyte sensing system of claim 13, wherein said patch and said on-skin unit comprise corresponding mechanical securing means configured to secure said on-skin unit to said patch.

16. The analyte sensing system of claim 13, wherein said patch is coated and/or impregnated with an antimicrobial agent.

17. The analyte sensing system of claim 13, further comprising bioresorbable staples configured to secure said patch to skin when in use.

18. The analyte sensing system of claim 17, wherein said bioresorbable staples are coated with an antimicrobial agent.

19. The analyte sensing system of claim 12, wherein said on-skin unit is coated on at least a portion thereof with an antimicrobial agent.

20. The analyte sensing system of claim 12, wherein an antimicrobial property of said antimicrobial reference electrode is imparted by selecting a material for said antimicrobial reference electrode from silver, gold, platinum, palladium, iridium, zinc, copper, tin, antimony, bismuth, or mixtures thereof.

21. The analyte sensing system of claim 12, wherein an antimicrobial property of said antimicrobial reference electrode is imparted by coating a reference electrode at least partially with an antimicrobial agent to form said antimicrobial reference electrode.

22. The analyte sensing system of claim 21, wherein said antimicrobial agent circumferentially surrounds at least a portion of said reference electrode.