GENE DETECTION ASSAY FOR IMPROVING THE LIKELIHOOD OF AN EFFECTIVE RESPONSE TO A HER2 ANTIBODY CANCER THERAPY

  • US 20070166753A1
  • Filed: 03/23/2007
  • Published: 07/19/2007
  • Est. Priority Date: 05/19/2000
  • Status: Active Grant
First Claim
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1. A method for identifying and treating a patient disposed to respond favorably to a HER2 antibody, huMAb4D5-8, for treating breast cancer, which method comprises detecting her2 gene amplification in tumor cells in a tissue sample from the patient and treating the patient with her2 gene amplification with the HER2 antibody in an amount effective to treat the breast cancer, wherein the patient'"'"'s tumor cells express HER2 at a 0 or 1+ level by immunohistochemistry.

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