Process for preparing a synthetic intermediate for preparation of branched nucleosides
2 Assignments
0 Petitions
Accused Products
Abstract
A process is provided for the preparation of a key intermediate in the preparation of 2′-branched nucleoside compounds. The process includes contacting a protected precursor 3,4-O-isopropylidene-2-C-substituted-
118 Citations
42 Claims
- 1. A process of preparing a compound of Formula II
-
32. A process for preparing a 2-deoxy-2-alkyl-2-halo-lactone compound comprising:
-
a) reacting an isopropylidene, alkyl-substituted arabinono-1,5-lactone compound to provide a 2-deoxyalkyl-disubstituted isopropylidene arabinono-1,5-lactone substituted with a leaving group at the 2-position;
b) reacting the product from step a) with a fluorinating agent to provide a 2-deoxy-2-fluoro, alkyl-disubstituted isopropylidene ribono-1,5-lactone;
c) deprotecting the product from step b) to provide a 2-deoxy-2-fluoro, alkyl-disubstituted ribono-1,4-lactone as a major product and a 2-deoxy-2-fluoro, alkyl-disubstituted ribono-1,5-lactone as a minor product; and
d) optionally protecting one or more hydroxy groups on either one of the products from step c. - View Dependent Claims (33, 34, 35, 36, 39, 40, 41, 42)
-
Specification