Integrated physiologic monitoring systems and methods
First Claim
1. A physiologic monitoring system including a physiologic monitoring application-specific integrated circuit, the integrated circuit comprising:
- an integrated a real-time clock, for generating a set of real time indicators;
integrated amplification and filtering circuitry, for amplifying and filtering a set of electrical signals received from a first set of physiologic sensors to generate a first set of filtered electrical signals, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the first set of physiologic sensors; and
integrated digital control logic connected to the real-time clock and the amplification and filtering circuitry;
the digital control logic being configured to receive a first set of digital physiologic data derived from the first set of filtered electrical signals, receive a second set of digital physiologic data, wherein the second set of physiologic data includes physiologic data sampled with a different sampling rate than the first set of digital physiologic data, generate a time-stamped physiologic data packet from a real-time indicator, the first set of digital physiologic data and the second set of digital physiologic data; and
transmit the physiologic data packet for storage in a digital memory.
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Accused Products
Abstract
In some embodiments, a wearable physiologic monitor comprises a mixed analog and digital application-specific integrated circuit (ASIC) including signal conditioning circuitry, an A/D converter, a real-time clock, and digital control logic. The signal conditioning circuitry includes analog amplification circuitry, analog (continuous-time or switched capacitor) filtering circuitry before the A/D converter, and in some embodiments digital (DSP) filtering circuitry after the A/D converter. The monitor includes sensors such as electrocardiogram (ECG) electrodes, accelerometers, and a temperature sensor, some of which may be integrated on the ASIC. The digital control logic receives digital physiologic data sampled at different rates, assembles the data into physiologic data packets, time-stamps at least some of the packets, and periodically stores the packets in a digital memory. The monitor may include a disposable patch including the ASIC, and a reusable, removable digital memory such as flash memory card. Applications include ambulatory monitoring and quantitative titration of care.
628 Citations
73 Claims
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1. A physiologic monitoring system including a physiologic monitoring application-specific integrated circuit, the integrated circuit comprising:
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an integrated a real-time clock, for generating a set of real time indicators;
integrated amplification and filtering circuitry, for amplifying and filtering a set of electrical signals received from a first set of physiologic sensors to generate a first set of filtered electrical signals, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the first set of physiologic sensors; and
integrated digital control logic connected to the real-time clock and the amplification and filtering circuitry;
the digital control logic being configured to receive a first set of digital physiologic data derived from the first set of filtered electrical signals,receive a second set of digital physiologic data, wherein the second set of physiologic data includes physiologic data sampled with a different sampling rate than the first set of digital physiologic data, generate a time-stamped physiologic data packet from a real-time indicator, the first set of digital physiologic data and the second set of digital physiologic data; and
transmit the physiologic data packet for storage in a digital memory. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A wearable physiologic monitoring system comprising:
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a battery;
a plurality of electrocardiogram electrodes to be applied to a subject;
a removable digital memory; and
an application-specific integrated circuit connected to the removable digital memory, the battery, and the plurality of electrocardiogram electrodes, the integrated circuit comprising;
a real time clock for generating a set of real-time indicators;
amplification and filtering circuitry connected to the plurality of electrocardiogram electrodes, for amplifying and filtering a set of electrical signals received from the electrocardiogram electrodes to generate a set of filtered electrocardiogram data, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the electrocardiogram electrodes; and
digital control logic connected to the real-time clock and the amplification and filtering circuitry, the digital control logic being configured to assemble a time-stamped data packet including a set of digital electrocardiogram data derived from the filtered electrocardiogram data, the data packet being time-stamped according to a real-time indicator, and transmit the data packet for storage in the removable digital memory. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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62. A wearable physiologic monitoring system comprising:
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a battery;
a plurality of electrocardiogram electrodes to be applied to a subject;
a digital memory; and
an application-specific integrated circuit connected to the digital memory, the battery, and the plurality of electrocardiogram electrodes, the integrated circuit comprising;
a real time clock for generating a set of real-time indicators;
amplification and filtering circuitry connected to the plurality of electrocardiogram electrodes, for amplifying and filtering a set of electrical signals received from the electrocardiogram electrodes to generate a set of filtered electrocardiogram data, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the electrocardiogram electrodes; and
digital control logic connected to the real-time clock and the amplification and filtering circuitry, the digital control logic being configured to time-stamp a set of digital electrocardiogram data derived from the filtered electrocardiogram data according to a real-time indicator, and transmit a set of time-stamped digital electrocardiogram data for storage in the digital memory.
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63. A physiologic monitoring system comprising:
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electrocardiogram sensing means for sensing a set of electrocardiogram signals generated along a subject'"'"'s skin;
wearable means connected to the electrocardiogram sending means and comprising;
digital memory means; and
an application-specific integrated circuit comprising real-time means for generating a set of real time indicators;
signal conditioning means for amplifying and filtering a set of electrical signals received from the electrocardiogram sensing means; and
digital control logic connected to the signal conditioning means, for time-stamping according to the set of real-time indicators a set of digital electrocardiogram data derived from the electrical signals, and transmitting a set of time-stamped digital electrocardiogram data to the digital memory means for storage.
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64. A wearable physiologic monitoring system comprising:
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a digital memory;
a wearable patch comprising an integrated circuit connected to a plurality of electrocardiogram electrodes and the digital memory, the integrated circuit comprising;
a real-time clock for generating a set of real time indicators;
a temperature sensor for generating a set of subject temperature indicators;
an accelerometer for generating a set of subject acceleration indicators;
amplification and filtering circuitry connected to the plurality of electrocardiogram electrodes, for amplifying and filtering a set of electrical signals received from the electrocardiogram electrodes, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the electrocardiogram electrodes; and
digital control logic connected to the amplification and filtering circuitry, the temperature sensor and the accelerometer, the digital control logic being configured to assemble a physiologic data packet including digital electrocardiogram data derived from the set of electrical signals, temperature data derived from the set of subject temperature indicators, and acceleration data derived from the subject acceleration indicators, time-stamp the data packet according to a real-time indicator, and transmit the data packet to the digital memory for storage.
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65. A physiologic monitoring method comprising:
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sensing a first set of physiologic indicators generated by a subject using a first sensor set; and
employing a mixed analog and digital application-specific integrated circuit comprising integrated signal conditioning circuitry and digital control logic to generate a real-time indicator, amplify and filter the first set of physiologic indicators, generate a first set of digital physiologic data from the first set of physiologic indicators at a first sampling rate, assemble the first set of digital physiologic data into a data packet, time-stamp the data packet according to the real-time indicator, and transmit the data packet for storage in a removable digital memory connected to the integrated circuit. - View Dependent Claims (66, 67, 68, 69)
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70. A method of providing quantitative titration of care to a subject, comprising:
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using a first wearable physiologic monitor to record a first set of subject physiologic data indicative of a first physiologic condition of a subject in a first treatment state, the first of subject physiologic data including a first set of electrocardiogram data and a first set of non-electrocardiogram data, wherein the first physiologic monitor includes a set of electrocardiogram sensors and a set of non-electrocardiogram physiologic sensors, a digital memory, and digital control logic connected to the electrocardiogram sensors, the non-electrocardiogram physiologic sensors and the digital memory, and wherein the digital control logic transmits physiologic data sensed by the electrocardiogram sensors and the non-electrocardiogram physiologic sensors for storage in the digital memory;
performing a first quantitative evaluation of the first physiologic condition according to the first set of physiologic data;
recording a second set of subject physiologic data indicative of a second physiologic condition of the subject in a second treatment state, the second set of subject physiologic data includes a second set of electrocardiogram data and a second set of non-electrocardiogram data;
performing a second quantitative evaluation of the second physiologic condition according to the second set of physiologic data;
performing a quantitative comparison of the first quantitative evaluation to the second quantitative evaluation; and
making a treatment decision for the subject according to the comparison. - View Dependent Claims (71, 72, 73)
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Specification