LIPID THERAPY
First Claim
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1. A method comprising:
- introducing into a blood stream or tissue a delipidated high density lipoprotein (HDL) and a bioactive agent.
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Abstract
A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
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Citations
30 Claims
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1. A method comprising:
introducing into a blood stream or tissue a delipidated high density lipoprotein (HDL) and a bioactive agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A composition comprising:
a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A composition comprising:
Apo-A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. - View Dependent Claims (19, 20)
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21. A composition comprising:
Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
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22. A method comprising:
delivering to a treatment site within a lumen of a blood vessel, in a wall of the blood vessel, or beyond the blood vessel by a percutaneous transluminal route an agent comprising at least one of a delipidated HDL, an HDL-mimicking peptide having a property to bind cholesterol, and a cyclodextrin. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
Specification