ANTI-CLOTTING APPARATUS AND METHODS FOR FLUID HANDLING SYSTEM

• US 20070239096A1
• Filed: 04/11/2007
• Published: 10/11/2007
• Est. Priority Date: 04/11/2006
• Status: Active Grant

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Keenan, Richard, Chiou, Jeff
• Granted Patent: US 8,425,444 B2
• Time in Patent Office: Days
• US Class Current: 604/4.10
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: A61M 1/152 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1566 Means for adding solutions or substances to the treating fluid
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 2005/1404 Keep vein-open rate [KVO], i.e. low flow rate
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 29/00 Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object G01N3/00, G01N5/00, G01N7/00, G01N9/00, G01N11/00, G01N13/00, G01N15/00, G01N17/00, G01N19/00, G01N21/00, G01N22/00, G01N23/00, G01N24/00, G01N25/00, G01N27/00 take precedence

Abstract

Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. In some embodiments, a method for maintaining clear passageways in an extracorporeal blood flow system includes intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. In some embodiments, an extracorporeal blood flow system includes a passageway and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.

Claims

1. A method for maintaining clear passageways in an extracorporeal blood flow system comprising:

intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system.

2. The method of claim 1, wherein intermittently providing one or more anti-clotting agents comprises intermittently providing ultrasonic energy to the passageway.

3. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a cleaning solution that is thermally stable at room temperatures.

4. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a mixture having approximately 1% TERGAZYME in saline.

5. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a mixture comprising sodium heparin.

6. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a mixture comprising K2EDTA.

7. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a mixture comprising K3EDTA.

8. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a mixture comprising Potassium Oxalate/sodium fluoride.

9. The method of claim 1, wherein intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system comprises delivery of a mixture comprising Sodium Citrate/Citric acid.

10. An extracorporeal blood flow system comprising:

a passageway; and

a device operatively connected to the passageway to provide one or more anti-clotting agents to a least a portion of said passageway.

11. The system of claim 10, further comprising:

a bubble injector configured to separate drawn blood into an analyze and return portions;

a waste bladder configured to receive the analyze portion after it is analyzed; and

a pump configured to return the return portion to a patient.

12. An apparatus for preventing blood coagulation in a blood flow system comprising:

a blood flow passageway; and

an ultrasonic vibration device configured to transmit ultrasonic energy into the flow passageway.

13. The apparatus of claim 12, wherein the ultrasonic vibration device comprises an ultrasonic generator and an ultrasonic horn.

14. The apparatus of claim 12, wherein the ultrasonic vibration device is movable and can be placed in contact with a blood-containing portion of the blood flow system.

15. The apparatus of claim 12, wherein the ultrasonic vibration device is configured to transmit energy at a frequency in the range of approximately 15 to 60 kHz.

16. A method of correcting an analyte measurement for dilution, the method comprising:

determining a ratio of volume of anticoagulant solution to total volume;

using the equation C0=C0′

(1+δ

V/V0) to correct for dilution; and

storing the corrected measurement in a memory.

17. The method of claim 16, further comprising:

providing an accurately-measured volume of anticoagulant solution; and

measuring the amount of anticoagulation analyte in the sampling system.