Device for Ophthalmic Drug Delivery

• US 20070244442A1
• Filed: 05/16/2007
• Published: 10/18/2007
• Est. Priority Date: 12/22/2004
• Status: Abandoned Application

• Current Assignee: Alcon Incorporated
• Original Assignee: Alcon Incorporated
• Inventors: Chowhan, Masood
• Application Number:
  US11/749,543
• Publication Number:
  US 20070244442A1
• Time in Patent Office: Days
• US Class Current: 604/191
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02

Abstract

An ophthalmic drug delivery device having two actuation assemblies for dispensing incompatible dosage forms and facilitating the prevention of dosage form reflux.

Claims

1. An ophthalmic drug delivery device, comprising:

a body having a plunger chamber, a first actuation chamber, and a second actuation chamber;

a plunger assembly having a first sealing member slidably disposed within said plunger chamber;

a first actuation assembly having a first contact member disposed in said plunger chamber, a second sealing member slidably disposed in said first actuation chamber, and a spring member disposed between said first sealing member and said first contact member;

a second actuation assembly having a second contact member disposed in said plunger chamber and a third sealing member slidably disposed in said second actuation chamber; and

a cannula fluidly coupled to said first actuation chamber and said second actuation chamber.

2. The ophthalmic drug delivery device of claim 1 further comprising:

a first dosage form disposed in said first actuation chamber between said second sealing member and said cannula; and

a second dosage form disposed in said second actuation chamber between said third sealing member and said cannula.

3. The ophthalmic drug delivery device of claim 2 wherein said spring member enables dispensing of said first dosage form from said cannula prior to dispensing of said second dosage form from said cannula.

4. The ophthalmic drug delivery device of claim 3 wherein:

said plunger assembly is coupled to a displacing member;

movement of said displacing member toward said cannula causes said plunger assembly, said spring member, and said first actuation assembly to dispense said first dosage form from said cannula; and

further movement of said displacing member toward said cannula causes said plunger assembly and said second actuation assembly to dispense said second dosage form from said cannula.

5. The ophthalmic drug delivery device of claim 4 wherein said displacing member is a handle.

6. The ophthalmic drug delivery device of claim 4 wherein said displacing member is an automated assembly for displacing said first sealing member.

7. The ophthalmic drug delivery device of claim 3 wherein said first dosage form is incompatible with said second dosage form.

8. The ophthalmic drug delivery device of claim 3 wherein:

said first dosage form comprises an ophthalmically acceptable pharmaceutically agent; and

said second dosage form is for preventing reflux of said first dosage form after dispensing into an eye.

9. The ophthalmic drug delivery device of claim 8 wherein said second dosage form comprises a biocompatible polymer for preventing reflux of said first dosage form after dispensing into an eye.

10. An ophthalmic drug delivery device, comprising:

a body having a first actuation chamber and a second actuation chamber;

a first actuation assembly having a first sealing member slidably disposed in said first actuation chamber;

a second actuation assembly having a second sealing member slidably disposed in said second actuation chamber;

a plunger assembly for actuating said first actuation assembly independently of said second actuation assembly;

a cannula fluidly coupled to said first actuation chamber and said second actuation chamber, said cannula comprising a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of a human eye;

a first dosage form disposed in said first actuation chamber between said first sealing member and said cannula, said first dosage form comprising an ophthalmically acceptable pharmaceutically active agent; and

a second dosage form disposed in said second actuation chamber between said second sealing member and said cannula, wherein said second dosage form is for preventing reflux of said first dosage form after dispensing into an eye.

11. The ophthalmic drug delivery device of claim 10 wherein said second dosage form comprises a biocompatible polymer for preventing reflux of said first dosage form after dispensing into an eye.