Prosthetic Devie for Cartilage Repair

• US 20070244484A1
• Filed: 06/17/2004
• Published: 10/18/2007
• Est. Priority Date: 06/24/2003
• Status: Active Grant

• Current Assignee: Dr. H.C. Robert Mathys Stifung
• Original Assignee: Dr. H.C. Robert Mathys Stifung
• Inventors: Luginbuehl, Reto
• Granted Patent: US 8,163,033 B2
• Time in Patent Office: Days
• US Class Current: 606/86.R
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/3804 for elbows
• CPC Class Codes: A61F 2002/30004 the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30205 conical
• CPC Class Codes: A61F 2002/30224 cylindrical
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0014 having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3808 Endothelial cells
• CPC Class Codes: A61L 27/3813 Epithelial cells, e.g. keratinocytes, urothelial cells
• CPC Class Codes: A61L 27/3834 : Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
• CPC Class Codes: A61L 27/3852 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/46 : with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges

Abstract

A prosthetic device for repairing or replacing cartilage or cartilage-like tissue is described. The prosthetic device comprises at least one layer of highly oriented fibers, a base component and a stabilization area provided in between. Said fibers are aligned to more than 50% in a direction perpendicular to the base component.

Claims

1. A prosthetic device for repairing or replacing cartilage or cartilage like-tissue (1) comprising:

at least one layer comprising at least partially oriented fibers (2),

a base component (4) to anchor said at least one layer of fibers (2) in subchondral environment and

a stabilization area (3) provided between said at least one layer comprising fibers (2) and said base component (4),

wherein said fibers (2) are aligned essentially in parallel to the insertion axis of the prosthetic device and form a brush-like structure.

2. The device according to claim 1, wherein said fibers (2) are aligned to more than 50, preferably more than 90%.

3. The device according to claim 1, wherein the fiber material (2) includes a mineral material, synthetic polymers or molecules, natural polymers or molecules, biotechnologically derived polymers or molecules, biomacromolecules, or any combination thereof.

4. The device according to claim 3,

wherein the fiber diameter is in a range of 50 nm to 1 mm.

5. The device according to claim 4,

wherein said fiber diameter is in a range of 1 μ

m to 250 μ

m.

6. The device according to 3,

wherein the fibers (2) have a liquid absorbing capacity in a range of 0.1 to 99.9%.

7. The device according to claim 6,

wherein said liquid absorbing capacity is in a range of 20.0 to 99.0%.

8. The device according to claim 6,

wherein the liquid is an aqueous solution and/or body fluids.

9. The device according to claim 1, wherein the base component (4) comprises a material used as a bone substitute.

10. The device according to claim 9, wherein said bone substitute is a mineral material, synthetic polymers or molecules, natural polymers or molecules, biotechnologically derived polymers or molecules, biomacromolecules, or any combination thereof.

11. The device according to claim 9,

wherein said material is a synthetic ceramic containing at least one of the following components:

calcium phosphate, calcium sulfate, calcium carbonate, or any mixture thereof.

12. The device according to claim 11,

wherein said calciumphosphate containing at least one of the following components:

di-calciumphosphatedihydrate (CaHP0₄×

2H₂0), dicalciumphosphate (CaHP0₄), alpha-tricalciumphosphate (alpha-Ca₃(P0₄)₂), beta-tricalciumphosphate (betaCa₃(P0₄)₂), calcium deficient hydroxylapatite (Ca₉(P0₄)₅(HP0₄)OH), hydroxylapatite (Ca₁₀(P0₄)₆OH₂), carbonated apatite (Ca₁₀(P0₄)₃(C0₃)₃) (OH)₂) fluorapatite (Ca₁₀(P0₄)₆(F,OH)₂), chlorapatite (Ca₁₀(P0₄)₆(Cl,OH)₂), whitlockite ((Ca,Mg)₃(P0₄)₂), tetracalciumphosphate (Ca₄(P0₄)₂0), oxyapatite (Ca₁₀(P0₄)₆0), beta-calciumpyrophosphate (beta-Ca₂(P₂0₇), alpha-calciumpyrophosphate, gamma-calcium-pyrophosphate, octacalciumphosphate (Ca₈H₂ (P0₄)₆×

5H₂0).

13. The device according to claim 9,

wherein said material is a synthetic ceramic containing metallic, semimetallic ions, and/or non-metallic ions, preferably magnesium, silicon, sodium, potassium, and/or lithium.

14. The device according to claims 9,

wherein the material is a composite material comprising at least a polymer component and a mineral phase.

15. The device according to claim 9,

wherein the bone substitute material is highly porous with interconnecting pores.

16. The device according to claim 9, wherein the shape of the base component (4) is round, cylindrical, or conical.

17. The device according to claim 16,

wherein the diameter of the base component (4) ranges between 2 and 30 mm, with a height being 1 to 30 mm.

18. The device according to claim 16, wherein the diameter of the base component (4) ranges between 4 and 20 mm, with a preferred height being between 1 to 6 mm.

19. The device according to claim 1, wherein said stabilization area (3) is a zone comprising at least one layer.

20. The device according to claim 19,

wherein said zone has a thickness of 1 nm to 1 mm.

21. The device according to claim 19, wherein said zone is porous.

22. The device according to claim 19, wherein the layer system is composed of a chemical substance.

23. The device according to claim 1, further comprising at least one externally added component.

24. The device according to claim 23,

wherein said components are cells of different origin.

25. The device according to claim 24,

wherein said cells are autologous cells, allogenous cells, xenogenous cells, transfected cells and/or genetically engineered cells.

26. The device according to claim 23,

wherein chondrocytes, chondral progenitor cells, pluripotent cells, tutipotent cells or combinations thereof are present throughout the fiber layer(s) (2).

27. The device according to claim 23,

wherein osteoplasts, osteo progenitor cells, pluripotent cells, tutipotent cells or combinations thereof are present throughout the base component (4).

28. The device according to claim 23, wherein blood or any fraction thereof is present throughout the base component (4).

29. The device according to claim 23,

wherein pharmaceutical compounds are contained.

30. A prosthetic device for repairing or replacing cartilage or cartilage like-tissue (1) comprising:

at least one layer comprising at least partially oriented fibers (2),

a base component (4) to anchor said at least one layer of fibers (2) in subchondral environment and

a stabilization area (3) provided between said at least one layer comprising fibers (2) and said base component (4),

wherein said fibers (2) are aligned essentially perpendicularly to a top surface of the base component facing the fibers.

31. A prosthetic device for repairing or replacing cartilage or cartilage like-tissue (1) comprising:

at least one layer comprising fibers (2),

a base component (4) to anchor said at least one layer of fibers (2) in subchondral environment and

a cell barrier layer provided between said at least one layer comprising fibers (2) and said base component (4).

32. The device of claim 31, wherein the prosthetic device is adapted to be implanted in articulating joints in humans and animals.

33. The device of claim 32 wherein the prosthetic device regenerates articulator cartilagenous tissue.