Human antibodies that bind human TNFa

  • US 20070249813A1
  • Filed: 04/17/2007
  • Published: 10/25/2007
  • Est. Priority Date: 02/09/1996
  • Status: Active Grant
First Claim
Patent Images

1. An antigen binding portion of an antibody that binds human TNFα

  • comprising a CDR3 domain comprising an amino acid sequence of SEQ ID NO;

    3, or modified from SEQ ID NO;

    3 by a single alanine substitution at position 1, 4, 5, 7 or 8 or by one to five conservative amino acid substitutions at positions 1, 3, 4, 6, 7, 8.

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