Device and Method for Measuring Physiological Parameters

• US 20070255122A1
• Filed: 08/30/2005
• Published: 11/01/2007
• Est. Priority Date: 08/30/2004
• Status: Abandoned Application

• Current Assignee: G.R. Enlightenment, Ltd.
• Original Assignee: G.R. Enlightenment, Ltd.
• Inventors: Vol, Alexander, Gribova, Orna
• Application Number:
  US11/661,422
• Publication Number:
  US 20070255122A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 2560/0468 Built-in electrodes
• CPC Class Codes: A61B 2560/0475 Special features of memory means, e.g. removable memory cards
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0024 for multiple sensor units attached to the patient, e.g. using a body or personal area network
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02035 Determining blood viscosity
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/02455 provided with high/low alarm devices
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/1101 Detecting tremor
• CPC Class Codes: A61B 5/14532 : for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/164 : Lie detection
• CPC Class Codes: A61B 5/24 : Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/332 : Portable devices specially adapted therefor
• CPC Class Codes: A61B 5/369 : Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 : Electromyography [EMG]
• CPC Class Codes: A61B 5/4035 : Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4261 : Evaluating exocrine secretion production A61B3/101 takes precedence
• CPC Class Codes: A61B 5/441 : Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 5/486 : Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61B 5/4884 : inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/6804 : Garments; Clothes
• CPC Class Codes: A61B 5/681 : Wristwatch-type devices
• CPC Class Codes: A61B 5/6828 : Leg
• CPC Class Codes: A61B 5/6829 : Foot or ankle
• CPC Class Codes: A61B 5/6833 : Adhesive patches
• CPC Class Codes: A61B 5/7475 : User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: A61B 7/00 : Instruments for auscultation

Abstract

Device and method for measuring physiological parameters of a biological being comprising: at least two spaced apart electrodes at least one of which is in contact with-the being for providing a bio-potential measurement including a low frequency AC voltage and/or a DC voltage wherein one of the electrodes is a reference electrode providing a reference for the DC voltage, the low frequency AC voltage and/or DC voltage measurement used to determine the physiological parameters. The device can be built in many forms (e.g. a wrist watch, torso strap, grip, etc); can measure physiological parameters including those related to diabetes (BGL), cardiovascular, organ, tissue, brain and neural function, local and limb metabolic condition, pharmacokinetic, pharmaco-dynamics and psychological conditions, temperature, or combination thereof and their trends. The device can include an automatic alarm system for warning a patient of an out of tolerance condition.

Claims

1. A device for measuring physiological parameters of a biological being comprising:

at least two spaced apart electrodes at least one of which is in contact with the biological being for providing a bio-potential measurement including a low frequency AC voltage and/or a DC voltage in which one of said at least two electrodes is a reference electrode providing a reference for said DC voltage, wherein said low frequency AC voltage and/or DC voltage of said bio-potential measurement is used to determine said physiological parameters.

2. The device according to claim 1, wherein the electrodes further measure high frequency AC voltage.

3. The device according to claim 1, wherein the physiological parameters include at least one of blood glucose level, cardiovascular function, blood pressure, organ function, tissue function, brain function, neural function, local and/or limb metabolic condition, pharmacokinetics, pharmaco-dynamics psychological condition, temperature, or any combination of these and their trends.

4. The device according to claim 1, wherein it further comprises additional contact or non-contact sensors of any one, or combination of the sensor types including:

pulse-wave, motion, temperature, acoustic, electro-magnetic, acidity and perspiration.

5. The device according to claim 1, wherein at least some of the electrodes are used in passive sensors.

6. The device according to claim 1, wherein the electrodes are two or more biocompatible electrodes composed of different conductive materials.

7. The device according to claim 1, wherein it is multi-parametric and multi-diagnostic device.

8. The device according to claim 1, wherein at least two of the electrodes are disposed in spaced apart cross-sections of a limb of the biological being.

9. The device according to claim 1, wherein all its sensors and electrodes are of the non-invasive type.

10. The device according to claim 1, wherein it is adapted to be a continuous measuring device thereby allowing monitoring of the physiological parameters.

11. The device according to claim 1, wherein it is adapted to provide trend analysis of the physiological parameters.

12. The device according to claim 1, wherein the electrodes are constituted by an array of electrodes and/or sensors or combination thereof.

13. The device according to claim 12, wherein measurements can be made between any of the electrodes or sensors of the array.

14. The device according to claim 1, wherein it is adapted to be worn on a limb, head or torso of the biological being.

15. The device according to claim 1, further comprising a signal processor for providing a warning of critical changes and/or rate of changes in the physiological parameters of the biological being.

16. The device according to claim 1, further comprising a programmed cartridge for individual periodic calibration of the device during routine clinical calibration tests.

17. The device according to claim 1, further comprising a data input unit for inputting any one of (a) the results of blood glucose measurements obtained by known methods to serve as reference values for calibrating said device and providing an indication of changes occurring in the patient'"'"'s condition, (b) dosages of the patient'"'"'s insulin, (c) oral hypoglycemic drugs, (d) patient'"'"'s food intake and (e) medications used by the biological being.

18. The device according to claim 1, further comprising, or adapted for use with, a display for displaying one or more of (a) data input to the device, (b) measurements made by the device and (c) parameters calculated by the device.

19. A method for measuring physiological parameters of a biological being comprising:

(a) providing a device according to claim 1;

(b) contacting said device with a biological being, (c) measuring at least a DC voltage and/or a low frequency AC voltage of the biological being.

20. The method according to claim 19, further comprising obtaining baseline physiological data of a patient and comparing the measured physiological parameters of the biological being with said baseline data.

21. A device for use in measuring one or more physiological parameters of a biological being, the device being configured as a passive sensing device and comprising at least two spaced apart electrodes, at least one said at least two electrodes being intended to be in contact with the biological being for providing a bio-potential measurement including a low frequency AC voltage and/or a DC voltage, one of said at least two electrodes being a reference electrode providing a reference for the DC voltage, the device thereby enabling use of the low and high frequency AC voltage and/or DC voltage of the bio-potential measurement to determine one or more physiological parameters.

22. A device for use in measuring one or more physiological parameters of a biological being, the device being configured as a passive sensing device and comprising:

biocompatible electrodes including at least two electrodes composed of different conductive materials.