Diagnostic Sensor

• US 20070287359A1
• Filed: 03/30/2004
• Published: 12/13/2007
• Est. Priority Date: 02/26/2004
• Status: Abandoned Application

• Current Assignee: Pixen Incorporated
• Original Assignee: Pixen Incorporated
• Inventors: Urushihata, Naoki, Tajima, Yukinobu, Yanagawa, Hideki
• Application Number:
  US10/590,312
• Publication Number:
  US 20070287359A1
• Time in Patent Office: Days
• US Class Current: 450/89
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

An object of the present invention is to provide a diagnostic sensor and a diagnostic system capable of easily detecting abnormality in a human body by a simple apparatus without using a conventional testing method of removing a part of tissues and/or taking blood, which gives pain to the patient, and examining the part of tissues and/or blood under a microscope for long time.

A diagnostic sensor of the present invention includes: detecting means (2) for detecting any of various pathogens existing in a part of a living body and/or body fluid of the living body or a gas emitted from the living body, or an antigen (S) or ligand corresponding to abnormality or disease; and signal generating means (semiconductor integrated circuit 1) for generating a signal when the detecting means (2) detects any of the pathogens, antigen (S), or ligand. In the diagnostic sensor (A) of the present invention or a diagnostic system (B) of the present invention using the diagnostic sensor, an electric change is generated when a pathogen, antigen (S), or ligand as a cause of development of odor at the time of abnormality, so that by checking a signal from the sensor, the presence or absence of abnormality can be easily determined. Thus, abnormality in a human body can be detected without removing a part of tissues and/or taking blood, which gives pain to the patient.

Claims

1. A diagnostic sensor comprising:

detecting means for detecting any of various pathogens existing in a part of a living body and/or body fluid of the living body or a gas emitted from the living body, or an antigen or ligand corresponding to abnormality or disease; and

signal generating means for generating a signal when the detecting means detects any of the pathogens, antigen, or ligand.

2. The diagnostic sensor according to claim 1, wherein the detecting means is formed by applying or attaching an antibody or protein on or near an integrated circuit formed on a semiconductor substrate,

a part to which the antibody or protein is applied or attached and the integrated circuit are electrically connected to each other via a conductor,

the signal generating means is formed in the integrated circuit, and

when a surface acoustic wave current which is generated when the antibody and the antigen bind to each other or the protein and the ligand bind to each other is transmitted via the conductor to the integrated circuit, a signal corresponding to the surface acoustic wave current is transmitted to the outside of the integrated circuit.

3. A diagnostic system using the diagnostic sensor according to claim 1, comprising:

signal amplifying means for amplifying a signal generated by the diagnostic sensor;

storing means for storing, as a base signal, a signal generated when the diagnostic sensor does not detect a pathogen, antigen, or ligand;

control means; and

display means,

wherein the control means compares a signal generated by the diagnostic sensor with the base signal stored in the storing means, thereby detecting whether or not the signal generated by the diagnostic sensor is a signal generated in the case where a pathogen, antigen, or ligand is detected.

4. A diagnostic system using the diagnostic sensor according to claim 1 and a computer network, comprising:

reading means provided on a patient side, for reading a signal generated by the diagnostic sensor and generating an electric signal;

a patient-side computer for sending the electric signal from the reading means to the network; and

a diagnosing-side computer for receiving the signal from the reading means sent via the network,

wherein the diagnosing-side computer comprises;

storing means for pre-storing, as a base signal, a signal generated by the reading means in the case where the diagnostic sensor does not detect a pathogen, antigen, or ligand;

comparing means for comparing the signal sent via the network with the base signal; and

determining means for determining the state of the patient side corresponding to the signal sent via the network on the basis of an output signal of the comparing means.

5. A brassiere formed in such a manner that a housing part for housing the diagnostic sensor according to claim 1 is formed, and

in the case where abnormality occurs in a mamma, an antigen or ligand as a cause of the abnormality is detected by the diagnostic sensor in the housing part, and the abnormality is notified.

6. A diagnostic system using the diagnostic sensor according to claim 2, comprising:

signal amplifying means for amplifying a signal generated by the diagnostic sensor;

storing means for storing, as a base signal, a signal generated when the diagnostic sensor does not detect a pathogen, antigen, or ligand;

control means; and

display means,

wherein the control means compares a signal generated by the diagnostic sensor with the base signal stored in the storing means, thereby detecting whether or not the signal generated by the diagnostic sensor is a signal generated in the case where a pathogen, antigen, or ligand is detected.

7. A diagnostic system using the diagnostic sensor according to claim 2 and a computer network, comprising:

reading means provided on a patient side, for reading a signal generated by the diagnostic sensor and generating an electric signal;

a patient-side computer for sending the electric signal from the reading means to the network; and

a diagnosing-side computer for receiving the signal from the reading means sent via the network,

wherein the diagnosing-side computer comprises;

storing means for pre-storing, as a base signal, a signal generated by the reading means in the case where the diagnostic sensor does not detect a pathogen, antigen, or ligand;

comparing means for comparing the signal sent via the network with the base signal; and

determining means for determining the state of the patient side corresponding to the signal sent via the network on the basis of an output signal of the comparing means.

8. A brassiere formed in such a manner that a housing part for housing the diagnostic sensor according to claim 2 is formed, and

in the case where abnormality occurs in a mamma, an antigen or ligand as a cause of the abnormality is detected by the diagnostic sensor in the housing part, and the abnormality is notified.

9. A brassiere formed in such a manner that a housing part for housing the diagnostic sensor according to claim 3 is formed, and

in the case where abnormality occurs in a mamma, an antigen or ligand as a cause of the abnormality is detected by the diagnostic sensor in the housing part, and the abnormality is notified.

10. A brassiere formed in such a manner that a housing part for housing the diagnostic sensor according to claim 4 is formed, and

in the case where abnormality occurs in a mamma, an antigen or ligand as a cause of the abnormality is detected by the diagnostic sensor in the housing part, and the abnormality is notified.

11. A brassiere formed in such a manner that a housing part for housing the diagnostic sensor according to claim 6 is formed, and

in the case where abnormality occurs in a mamma, an antigen or ligand as a cause of the abnormality is detected by the diagnostic sensor in the housing part, and the abnormality is notified.

12. A brassiere formed in such a manner that a housing part for housing the diagnostic sensor according to claim 7 is formed, and

in the case where abnormality occurs in a mamma, an antigen or ligand as a cause of the abnormality is detected by the diagnostic sensor in the housing part, and the abnormality is notified.