MODIFIED RELEASE FORMULATIONS OF A BUPROPION SALT
First Claim
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1. A controlled release composition comprising:
- a therapeutically effective amount of bupropion hydrobromide;
wherein 0% to 40% of said bupropion hydrobromide is released after 2 hours;
from 40% to 75% of said bupropion hydrobromide is released after 4 hours;
not less than 75% of said bupropion hydrobromide is released after 8 hours; and
not less than 85% of said bupropion hydrobromide is released after 16 hours.
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Abstract
The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
48 Citations
2 Claims
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1. A controlled release composition comprising:
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a therapeutically effective amount of bupropion hydrobromide;
wherein 0% to 40% of said bupropion hydrobromide is released after 2 hours;
from 40% to 75% of said bupropion hydrobromide is released after 4 hours;
not less than 75% of said bupropion hydrobromide is released after 8 hours; and
not less than 85% of said bupropion hydrobromide is released after 16 hours.
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2. A controlled release composition comprising:
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a therapeutically effective amount of bupropion hydrobromide;
wherein 0% to 20% of said bupropion hydrobromide is released after 2 hours;
from 15% to 45% of said bupropion hydrobromide is released after 4 hours;
from 40% to 90% of said bupropion hydrobromide is released after 8 hours; and
not less than 80% of said bupropion hydrobromide is released after 16 hours.
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Specification