Biocompatible Coating of Medical Devices

• US 20080003256A1
• Filed: 07/05/2005
• Published: 01/03/2008
• Est. Priority Date: 07/05/2004
• Status: Active Grant

• Current Assignee: Katholieke Universiteit Leuven
• Original Assignee: Katholieke Universiteit Leuven
• Inventors: Van Humbeeck, Jan, Martens, Johan, De Scheerder, Ivan
• Granted Patent: US 8,512,734 B2
• Time in Patent Office: Days
• US Class Current: 424/425
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

A coated implantable medical device is described, wherein the coating comprises a coating matrix and particles of one or more molecular sieves, preferably zeolite of zeogrid particles, optionally loaded with one or more bioactive agents. The coating matrix itself can function as a second drug-carrying interface. The coating comprising the molecular sieve material has an excellent biocompatibility and allows suitable drug delivery into the body of an animal, preferably a mammal and most preferably a human.

Claims

1-21. -21. (canceled)

22. A composition for coating an implantable medical device, said composition comprising:

a) a coating matrix, and

b) particles of one or more molecular sieves, wherein said particles of said one or more molecular sieves comprise, within their pores, one or more bioactive agents.

23. The composition of claim 22, for controlled release of a bioactive agent, wherein the size of said pores of said one or more molecular sieve particles is selected to ensure controlled release rate of said bioactive agent.

24. The composition of claim 22, wherein said coating matrix comprises one or more bioactive agents.

25. The composition of claim 24, wherein said one or more bioactive agents comprised in said coating matrix is the same as one or more of said bioactive agents comprised in said molecular sieve material.

26. The composition of claim 22, wherein said implantable medical device is a stent.

27. The composition of claim 22, wherein said molecular sieve is a silicate molecular sieve.

28. The composition of claim 22, wherein said molecular sieve is a zeogrid.

29. The composition of claim 22, wherein said coating matrix consists essentially of cis-hydrogenated fatty acids.

30. An implantable medical device coated with the composition of claim 22.

31. The implantable medical device of claim 30, characterized in that said particles of said one or more molecular sieves are embedded within said matrix.

32. The implantable medical device of claim 30, characterized in that said particles of said one or more molecular sieves are glued to the surface of said implantable device and are covered by said matrix.

33. The implantable medical device of claim 30, which comprises structural cavities on its inner and/or outer surface.

34. The implantable medical device of claim 33, wherein said structural cavities are filled with said matrix.

35. The implantable medical device of claim 33, wherein the surface of said implantable medical device is not coated with said coating composition, with the exception of said structural cavities.

36. The implantable medical device of claim 35, wherein the surface of said implantable medical device is coated with a second matrix which is different from the matrix comprised in said structural cavities.

39. A method for delivering suitable amounts of one or more bioactive agents into a body portion during or following a medical procedure, said method comprising, introducing into said body portion an implantable medical device according to claim 30.

40. The method according to claim 39, which is a method of treatment of a patient at risk of prosthesis-induced restenosis.

37. A method for preparing a coating composition for an implantable device, said method comprising

a) providing

i) a coating matrix, and

ii) particles of one or more molecular sieves, wherein said particles of said one or more molecular sieves comprise, within their pores, one or more bioactive agents

b) mixing said coating matrix and said molecular sieve material to obtain said coating composition

38. The method of claim 37, wherein said coating matrix comprises a bioactive agent.