SOLID DISPERSING VACCINE COMPOSITION FOR ORAL DELIVERY
First Claim
1. A fast disintegrating oral solid vaccine dosage form comprising:
- an immunogenic amount of an antigenic preparation, said antigenic preparation comprising a microsphere-antigen complex;
an adjuvant, wherein said adjuvant enhances the absorption of the antigen or potentiates the immunogenic response;
a mucoadhesive substance; and
a low density dosage form matrix.
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Accused Products
Abstract
The invention disclosed herein relate to an oral vaccine in which the vaccine composition and adjuvant(s) are carried on a solid fast-dispersing dosage form. The vaccines are targeted toward mucosal tissue and the adjuvant serves to ensure sufficient residence time for the vaccine composition on the mucosal tissue to facilitate its absorption thereby. The fast-dispersing oral solid vaccine dosage form of the invention is particularly useful to administer the vaccine to patients that have difficulty swallowing medications. In one embodiment, the invention provides a fast disintegrating oral solid vaccine dosage form comprising: an immunogenic amount of an antigenic preparation, the antigenic preparation comprising a microsphere-antigen complex; an adjuvant, wherein the adjuvant enhances the absorption of the antigen or potentiates the immunogenic response; a mucoadhesive substance; and a low density dosage form matrix.
9 Citations
34 Claims
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1. A fast disintegrating oral solid vaccine dosage form comprising:
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an immunogenic amount of an antigenic preparation, said antigenic preparation comprising a microsphere-antigen complex;
an adjuvant, wherein said adjuvant enhances the absorption of the antigen or potentiates the immunogenic response;
a mucoadhesive substance; and
a low density dosage form matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A fast disintegrating oral solid vaccine dosage form comprising:
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an immunogenic amount of an antigenic preparation comprising tetanus toxoid (TT), said antigenic preparation comprising a microsphere-antigen complex;
an adjuvant, wherein said adjuvant enhances the absorption of the antigen or potentiates the immunogenic response;
a mucoadhesive substance; and
a low density dosage form matrix. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification