In vivo implantable coil assembly

• US 20080021525A1
• Filed: 07/17/2007
• Published: 01/24/2008
• Est. Priority Date: 07/17/2006
• Status: Active Grant

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V., University of Utah Research Foundation (State of Utah)
• Original Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Inventors: Kim, Sohee, Normann, Richard, Solzbacher, Florian, Harrison, Reid
• Granted Patent: US 8,521,303 B2
• Time in Patent Office: Days
• US Class Current: 607/61
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

An in-vivo implantable coil assembly includes a planar coil having at least one coil layer formed from conductive traces disposed in or on a polymer matrix. A ferrite platelet is bonded to a surface of the polymer matrix. Methods of making and using the in-vivo implantable coil assembly are also disclosed.

Claims

1. A method of making an in-vivo implantable coil assembly comprising the steps of:

a) coating a sacrificial separation layer onto a temporary substrate;

b) depositing a polymer layer onto the separation layer;

c) fabricating a thin film coil on the polymer layer;

d) forming electrical contacts on a top surface of the thin film coil;

e) separating the polymer layer from the temporary substrate; and

f) bonding the polymer layer to a ferrite substrate to form the in-vivo implantable coil assembly.

2. The method of claim 1, wherein the temporary substrate is reusable.

3. The method of claim 1, wherein the step of fabricating the thin film coil comprises the steps of:

a) forming a first metallization layer on the polymer layer;

b) patterning the first metallization layer to form a first coil layer;

c) depositing a second polymer layer embedding the first coil layer;

d) forming a second metallization layer on the second polymer layer having at least two electrical interconnections to the first metallization layer; and

e) patterning the second metallization layer to form a second coil layer.

4. The method of claim 3, wherein the steps of patterning the metallization layers are performed using photolithography.

5. The method of claim 1, wherein the step of fabricating the thin film coil comprises the step of depositing conductive material to form at least one coil layer onto the polymer layer.

6. The method of claim 1, wherein the step of separating the polymer layer from the substrate further comprises the step of chemically removing the separation layer.

7. The method of claim 1, wherein the polymer is selected from the group consisting of polyamide, benzocyclobutene, composites thereof, and combinations thereof.

8. An in-vivo implantable coil assembly comprising:

a planar coil having at least one coil layer formed by conductive traces disposed in a polymer matrix and exposed electrical contacts for connection to the coil layer(s); and

a ferrite platelet bonded to a surface of the polymer matrix.

9. The implantable coil assembly of claim 8 wherein the planar coil comprises a plurality of coil layers.

10. The implantable coil assembly of claim 9 wherein the exposed electrical contacts include at least one electrical contact for connection to each end of each coil layer to provide for alternative connection to the coil layers in a series and in a parallel arrangement.

11. The implantable coil assembly of claim 8 wherein the polymer is selected from the group consisting of polyamide, benzocyclobutene, composites thereof, and combinations thereof.

12. The implantable coil assembly of claim 8 wherein the conductive traces include gold.

13. The implantable coil assembly of claim 8 wherein the ferrite platelet comprises a low temperature co-fired ceramic material.

14. The implantable coil assembly of claim 8 wherein the ferrite platelet comprises a plurality of colloidal ferrite particles within a non-conducting medium.

15. The implantable coil assembly of claim 14 wherein the colloidal ferrite particles are nanoparticles.

16. The implantable coil assembly of claim 8 wherein the conductive trace width is 20 micrometers or less.

17. The implantable coil assembly of claim 8 wherein the conductive trace spacing is 20 micrometers or less.

18. The implantable coil assembly of claim 8 wherein the ferrite platelet has a relative permeability of 200 or greater.

19. The in-vivo implantable planar coil of claim 8 wherein the polymer matrix has a thickness within the range of about 5 micrometers to about 30 micrometers.

20. The in-vivo implantable planar coil of claim 8 wherein the ferrite platelet has a thickness within the range of about 100 micrometers to about 200 micrometers.

21. A method of using an in-vivo implantable planar coil assembly in an integrated neural probe comprising the steps of:

a) providing a multilayer coil having a polymer substrate and bonded to a ferrite plate, a plurality of electrical contacts coupled to the multilayer coil and disposed on an upper surface of the multilayer coil to provide enable electrical connection to each layer of the multilayer coil; and

b) mounting the multilayer coil to a neural interface assembly to form an integrated neural probe.

22. The method of claim 21, further comprising the step of selectively connecting individual layers of the multilayer coil in a series configuration.

23. The method of claim 21, further comprising the step of selectively connecting individual layers of the multilayer coil in a parallel configuration.

24. The method of claim 21, further comprising the step of implanting the integrated neural probe into a living body.

25. The method of claim 21, further comprising the step of inductively coupling power into the integrated neural probe via the multilayer coil.