REDOX POLYMERS FOR USE IN ELECTROCHEMICAL-BASED SENSORS

• US 20080035479A1
• Filed: 10/19/2007
• Published: 02/14/2008
• Est. Priority Date: 07/28/2004
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Rodgers, James, LIU, Zuifang, Ulue, Geoffrey
• Granted Patent: US 7,592,151 B2
• Time in Patent Office: Days
• US Class Current: 204/403.14
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

Claims

1-9. -9. (canceled)

10. An electrochemical-based sensor comprising:

an electrode; and

a chemical composition coated on a surface of the electrode, the chemical composition including a redox polymer with;

a hydrophobic polymer backbone;

at least one hydrophilic polymer arm attached to the hydrophobic polymer backbone; and

a plurality of redox mediators attached to the at least one hydrophilic polymer arm.

11. The electrochemical-based sensor of claim 10, wherein the chemical composition further includes a redox enzyme.

12. The electrochemical-based sensor of claim 11, wherein the redox enzyme is a redox enzyme selected from the group consisting of glucose oxidase and glucose dehydrogenase.

13. The electrochemical-based sensor of claim 10, wherein the hydrophilic arm is formed from at least one of N-vinylpyrrolidone, hydroxyethyl methacrylate, N-isopropylacrylamide, glycerol methacrylate, acrylamide, and combinations thereof

14. The electrochemical-based sensor of claim 10, wherein the hydrophobic polymer backbone is a formed from at least one of methylmethacrylate, styrene, butyl methacrylate, and combinations thereof.