BIOMEDICAL VALVE DEVICES, SUPPORT FRAMES FOR USE IN SUCH DEVICES, AND RELATED METHODS

• US 20080046071A1
• Filed: 08/21/2007
• Published: 02/21/2008
• Est. Priority Date: 08/21/2006
• Status: Active Grant

• Current Assignee: Oregon Health & Science University
• Original Assignee: Oregon Health & Science University
• Inventors: PAVCNIK, DUSAN
• Granted Patent: US 8,257,429 B2
• Time in Patent Office: Days
• US Class Current: 623/1.24
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0066 stapled
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61L 27/3625 Vascular tissue, e.g. heart valves
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

Biomedical valve devices, support frames for use in such devices, methods of making such devices, and methods of treating animals, including humans, for valve-related conditions are described. The biomedical valve devices can includes a native tissue valve attached to a support frame or a tissue attached to a support frame in a manner to form a valve. The tissue valve or tissue can be autogenous to the animal being treated.

Claims

1. A biomedical valve device for implantation in a body vessel of an animal in need thereof, comprising:

a first frame member having a first closed circumference having a first length;

a second frame member connected to the first frame member, the second frame member having a second closed circumference having a second length that is less than the first length; and

a tissue valve attached to the second frame member.

2. The biomedical valve device according to claim 1, wherein the first frame member is formed from a single wire member.

3. The biomedical valve device according to claim 2, wherein the second frame member is formed from a single wire member.

4. The biomedical valve device according to claim 2, wherein the second frame member is formed from two or more wire members.

5. The biomedical valve device according to claim 1, wherein the second frame member includes at least first and second arms and wherein each of the at least first and second arms defines an angle such that the second frame member defines a base portion and an upper portion.

6. The biomedical valve device according to claim 5, wherein the first and second frame members for a support frame having a lengthwise axis, the base portion extending inward at a first angle relative to the lengthwise axis and the upper portion extending inward at a second angle relative to the lengthwise axis.

7. The biomedical valve device according to claim 6, wherein the second angle is smaller than the first angle.

8. The biomedical valve device according to claim 1, wherein the first frame member defines apical and lateral bends.

9. The biomedical valve device according to claim 8, wherein the first frame member defines at least one coil in at least one of the apical and lateral bends.

10. The biomedical valve device according to claim 1, wherein the second frame member defines apical and lateral bends.

11. The biomedical valve device according to claim 10, wherein the second frame member defines at least one coil in at least one of the apical and lateral bends.

12. The biomedical valve device according to claim 1, wherein the first frame member defines first and second apical bends and the second frame member defines third and fourth apical bends, at least one of the first, second, third, and fourth apical bends comprising a coil.

13. The biomedical valve device according to claim 1, further comprising at least one barb disposed on at least one of the first and second frame members.

14. The biomedical valve device according to claim 1, wherein the tissue valve comprises an autogenous valve harvested from said animal.

15. The biomedical valve device according to claim 1, wherein the tissue valve comprises a valve harvested from a different animal of the same species as said animal.

16. The biomedical valve device according to claim 1, wherein the tissue valve comprises a valve harvested from a different animal of a different species than said animal.

17. The biomedical valve device according to claim 14, wherein said animal is a human.

18. The biomedical valve device according to claim 15, wherein said animal is a human.

19. A biomedical valve device, comprising:

first and second interconnected frame members, the first frame member having a first axial length, the second frame member having a second axial length that is shorter than the first axial length, the second frame member defining a relatively wide base portion and a relatively narrow upper portion;

a tissue valve defining a valve orifice, the tissue valve attached to the second frame member such that the valve orifice is disposed on the upper portion of the second frame member.

20. A method of treating an animal, comprising the steps of:

providing a support frame comprising a first frame member having a first closed circumference having a first length and a second frame member connected to the first frame member, the second frame member having a second closed circumference having a second length that is less than the first length;

harvesting a tissue valve from said animal;

attaching the tissue valve to the support frame to form a biomedical valve device; and

implanting the biomedical valve device in a body vessel of said animal.