Systems for autofluorescent imaging and target ablation

• US 20080058649A1
• Filed: 08/24/2007
• Published: 03/06/2008
• Est. Priority Date: 04/12/2006
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Weaver, Thomas, Boyden, Edward, Leuthardt, Eric, Hyde, Roderick, Rivet, Dennis, Myhrvold, Nathan, Wood, Lowell, Ishikawa, Muriel
• Granted Patent: US 8,145,295 B2
• Time in Patent Office: Days
• US Class Current: 600/476
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 18/201 with beam delivery through a hollow tube, e.g. forming an articulated arm through a flexible conduit A61B18/22; Hand-pieces therefor
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2017/00066 intensity
• CPC Class Codes: A61B 2018/00208 actively driven, e.g. by a motor
• CPC Class Codes: A61B 2018/00345 Vascular system
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00505 Urinary tract
• CPC Class Codes: A61B 2018/00559 Female reproductive organs
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61B 2018/0066 without feedback, i.e. open loop control
• CPC Class Codes: A61B 2018/00702 Power or energy
• CPC Class Codes: A61B 2018/00785 Reflected power
• CPC Class Codes: A61B 2018/00904 Automatic detection of target tissue
• CPC Class Codes: A61B 2018/00922 by switching or controlling the treatment energy directly within the hand-piece
• CPC Class Codes: A61B 2018/00982 combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
• CPC Class Codes: A61B 2018/20361 with redirecting based on sensed condition, e.g. tissue analysis or tissue movement
• CPC Class Codes: A61B 2018/207 mixing two wavelengths
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 : by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 : for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 : using infrared radiation
• CPC Class Codes: A61B 5/0088 : for oral or dental tissue
• CPC Class Codes: A61B 5/0091 : for mammography
• CPC Class Codes: A61B 5/0097 : by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: A61B 5/0507 : using microwaves or terahertz waves
• CPC Class Codes: A61B 5/07 : Endoradiosondes
• CPC Class Codes: A61B 5/412 : Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4547 : Evaluating teeth
• CPC Class Codes: A61N 2005/0602 : for treatment of blood vessels
• CPC Class Codes: A61N 2005/0606 : Mouth
• CPC Class Codes: A61N 2005/0607 : Nose
• CPC Class Codes: A61N 2005/0609 : Stomach and/or esophagus
• CPC Class Codes: A61N 2005/061 : Bladder and/or urethra
• CPC Class Codes: A61N 2005/0626 : Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0644 : Handheld applicators
• CPC Class Codes: A61N 2005/0651 : Diodes
• CPC Class Codes: A61N 2005/0654 : Lamps
• CPC Class Codes: A61N 2005/0659 : infrared
• CPC Class Codes: A61N 2005/0661 : ultraviolet
• CPC Class Codes: A61N 2005/0663 : Coloured light
• CPC Class Codes: A61N 2005/1087 : Ions; Protons
• CPC Class Codes: A61N 2005/1089 : Electrons
• CPC Class Codes: A61N 5/01 : Devices for producing movement of radiation source during therapy A61N5/1077 takes precedence
• CPC Class Codes: A61N 5/0603 : for treatment of body cavities
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/0624 : for eliminating microbes, germs, bacteria on or in the body
• CPC Class Codes: A61N 5/067 : using laser light
• CPC Class Codes: A61N 5/10 : X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1001 : using radiation sources introduced into or applied onto the body; brachytherapy

Abstract

Apparatus, devices, methods, systems, computer programs and computing devices related to autofluorescent imaging and ablation are disclosed.

Claims

1. A method comprising:

receiving a first input associated with a first possible dataset, the first possible dataset including data representative of a fluorescent response;

determining data representative of a location of a target area at least partially based on the first possible dataset; and

providing a first possible output to a first motive source, the first possible output providing data representative of one or more parameters associated with movement of an untethered device in a lumen at least partially based on the location of the target area.

2. The method claim 1, wherein data representative of the fluorescent response includes data representative of a target fluorescent response.

3. The method claim 1, further comprising:

accessing the first possible dataset in response to the first input.

4. The method claim 1, further comprising:

generating the first possible dataset in response to the first input.

5. The method of claim 4, wherein generating the first possible dataset in response to the first input comprises:

determining data representative of the location of the target area at least partially based on the fluorescent response.

6. The method claim 1, further comprising:

generating the first possible output in response to the first input.

7. The method claim 1, further comprising:

determining a graphical illustration of the first possible dataset.

8. The method of claim 7, wherein determining a graphical illustration of the first possible dataset comprises:

determining a graphical illustration of the location of the target area.

9. The method of claim 7, wherein determining a graphical illustration of the first possible dataset comprises:

determining a graphical illustration of the one or more parameters associated with the movement of the untethered device.

10. The method claim 1, further comprising:

sending the first output associated with the first possible dataset.

11. The method claim 1, further comprising:

determining data representative of one or more characteristics of excitation energy for inducing the fluorescent response.

12. The method claim 1, further comprising:

determining data representative of one or more characteristics of ablation energy for at least partially ablating the target area.

13. A computer program product comprising:

a signal bearing medium bearing

at least one of one or more instructions for receiving a first input associated with a first possible dataset, the first possible dataset including data representative of a fluorescent response;

at least one of one or more instructions for determining data representative of a location of a target area at least partially based on the first possible dataset and

at least one of one or more instructions for providing a first possible output to a first motive source, the first possible output providing data representative of one or more parameters associated with movement of an untethered device in a lumen at least partially based on the location of the target area.

14. The computer program product of claim 13, further comprising:

one or more instructions for accessing the first possible dataset in response to the first input.

15. The computer program product of claim 13, further comprising:

one or more instructions for generating the first possible dataset in response to the first input.

16. The computer program product of claim 13, further comprising:

one or more instructions for generating the first possible output in response to the first input.

17. The computer program product of claim 13, further comprising:

one or more instructions for determining a graphical illustration of the first possible dataset.

18. The computer program product of claim 13, further comprising:

one or more instructions for sending the first output associated with the first possible dataset.

19. The computer program product of claim 13, wherein the signal bearing medium includes a computer-readable medium.

20. The computer program product of claim 13, wherein the signal bearing medium includes a recordable medium.

21. The computer program product of claim 13, wherein the signal bearing medium includes a communications medium.

22. A system comprising:

a computing device; and

one or more instructions that when executed on the computing device cause the computing device to receive a first input associated with a first possible dataset, the first possible dataset including data representative of a fluorescent response;

one or more instructions that when executed on the computing device cause the computing device to determine data representative of a location of a target area at least partially based on the first possible dataset and

one or more instructions that when executed on the computing device cause the computing device to provide a first possible output to a first motive source, the first possible output providing data representative of one or more parameters associated with movement of an untethered device in a lumen at least partially based on the location of the target area.

23. The system of claim 22, further comprising:

one or more instructions that when executed on the computing device cause the computing device to access the first possible dataset in response to the first input.

24. The system of claim 22, further comprising:

one or more instructions that when executed on the computing device cause the computing device to generate the first possible dataset in response to the first input.

25. The system of claim 22, further comprising:

one or more instructions that when executed on the computing device cause the computing device to generate the first possible output in response to the first input.

26. The system of claim 22, further comprising:

one or more instructions that when executed on the computing device cause the computing device to determine a graphical illustration of the first possible dataset.

27. The system of claim 22, further comprising:

one or more instructions that when executed on the computing device cause the computing device to send the first output associated with the first possible dataset.

28. The system of claim 22, wherein the computing device comprises:

one or more of a desktop computer, a workstation computer, a computing system comprised of a cluster of processors, a networked computer, a tablet personal computer, a laptop computer, or a personal digital assistant.

29. The system of claim 22, wherein the computing device is operable to communicate with a database to access the first possible dataset.