METHODS AND DEVICES FOR CONTROLLING BIOLOGIC MICROENVIRONMENTS
First Claim
Patent Images
1. A system for administering therapy to a portion of a body to be treated, comprising:
- at least one sensor for sensing environmental parameters proximate the portion to be treated;
at least one effector for changing at least one environmental parameter proximate the portion to be treated;
at least one reservoir, each reservoir storing a quantity of a therapeutic substance effective to treat the portion of the body;
release means operatively connected with said at least one reservoir to control release of at least a portion of the contents of said at least one reservoir proximate the portion to be treated; and
, at least one electronic processor, responsive to said at least one sensor, operative to control said at least one effector, and operative to control said release means;
whereby when said at least one effector changes at least one environmental parameter, the efficacy of the therapeutic substance released proximate the portion to be treated is improved.
3 Assignments
0 Petitions
Accused Products
Abstract
A microenvironment of a biological body is controlled, and more particularly, is measured, changed, and monitored with respect to temperature, pH level, moisture and other tissue parameters of a region of the body while, optionally, administering a therapeutic agent to that region.
203 Citations
39 Claims
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1. A system for administering therapy to a portion of a body to be treated, comprising:
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at least one sensor for sensing environmental parameters proximate the portion to be treated;
at least one effector for changing at least one environmental parameter proximate the portion to be treated;
at least one reservoir, each reservoir storing a quantity of a therapeutic substance effective to treat the portion of the body;
release means operatively connected with said at least one reservoir to control release of at least a portion of the contents of said at least one reservoir proximate the portion to be treated; and
,at least one electronic processor, responsive to said at least one sensor, operative to control said at least one effector, and operative to control said release means;
whereby when said at least one effector changes at least one environmental parameter, the efficacy of the therapeutic substance released proximate the portion to be treated is improved. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 35, 37, 38)
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15. A system for administering therapy to a portion of a body to be treated, comprising:
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at least one sensor for sensing environmental parameters proximate the portion to be treated;
at least one pH reservoir containing a substance operative to change pH proximate the portion of the body upon release proximate the portion of the body;
at least one therapeutic substance reservoir for storing a quantity of a therapeutic substance effective to treat the portion of the body;
release means operatively connected with said at least one pH reservoir and said at least one therapeutic reservoir to control release of at least a portion of the contents of each of said reservoirs, proximate the portion to be treated; and
,at least one electronic processor, responsive to said at least one sensor, operative to control said release means;
whereby when the pH proximate the portion to be treated is changed, the efficacy of the therapeutic substance released proximate the portion to be treated is improved.
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16. A system for administering therapy to a portion of a body to be treated, comprising:
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at least one sensor for sensing environmental parameters proximate the portion to be treated, said environmental parameters selected from the group consisting of;
temperature, pH, moisture, humidity, oxygen level, oxygenase, carbon dioxide level, rate of blood flow, nutrient level, osmolarity, pressure, vascular permeability, electrical charge, and therapeutic agents;
at least one effector for changing environmental parameters proximate the portion to be treated, including at least one effector for changing the temperature selected from the group consisting of;
resistive heater, ultrasonic heater, IR heater, RF heater, microwave heater, convection cooling device, conduction cooling device, and electronic cooling device;
at least one reservoir, each reservoir storing a quantity of a therapeutic substance effective to treat the portion of the body;
release means operatively connected with said at least one pH reservoir and said at least one therapeutic reservoir to control release of at least a portion of the contents of each of said reservoirs proximate the portion to be treated; and
,at least one electronic processor, responsive to said at least one sensor, operative to control said at least one effector, and operative to control said release means;
whereby said at least one effector for changing the temperature is operative, by changing the temperature proximate the portion to be treated, to change the pH proximate the portion to be treated, wherein the efficacy of the therapeutic substance released proximate the portion to be treated is improved.
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17-34. -34. (canceled)
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36. (canceled)
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39-259. -259. (canceled)
Specification