Implantable Biosensor and Methods of Use Thereof

  • US 20080154101A1
  • Filed: 09/27/2007
  • Published: 06/26/2008
  • Est. Priority Date: 09/27/2006
  • Status: Active Grant
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First Claim
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1. An analyte sensing device comprising:

  • an external control unit and an implantable sensor platform in wireless optical operable communication, wherein the sensor platform can pass though a 14 gauge or smaller bore needle,wherein the implantable sensor platform comprises, in operable communication,a photovoltaic device to receive optical power from the external control unit to serve as a power source for powering said implantable sensor platform,an optical receiver for detecting signals produced by the external control unit,a plurality of sensor elements operable for sensing of one or more analytesan interfacing circuit in operable communication with the sensor elements providing operating conditions to the sensor elements and controlled feedback for their operation, wherein the sensor element generates a sensor output signal proportional to the amount of analyte present,a signal processing circuit interfaced with the sensor output signal, wherein the signal processing circuit converts the sensor output current signal to digital pulses, converter in operable communication with the signal processing circuit, wherein the electrical to optical converter converts the digital pulses to optical pulses and transmits the optical pulse to the external control unit,a switching, multiplexing, demultiplexing logic circuits providing at least one function selected from initialization, power level check, circuit check, sensor selection, and sensor calibration,one or more optical components for facilitating wavelength selection, transmission and/or reflection, for the purpose of demultiplexing optical sources or signals of different wavelengths, anda biocompatible coating surrounding at least a portion of the sensor platform,wherein the external control unit comprises, in operable communication,an optical source suitable for powering the photovoltaic device of the implantable sensor platform,an optical receiver suitable for receiving one or more optical pulses from the implantable sensor platform and converting the optical pulses to electrical pulses,an optical transmitter suitable to transmit one or more optical pulses to the optical receivers of the implantable sensor platform, wherein the optical pulse relays instructions to the switching, multiplexing, demultiplexing and logic circuits of the implantable sensor platform to provide at least one function selected from initialization, power check, potentiostat circuit reconfiguration, sensor selection for analyte level measurement, and sensor calibration,an integrated circuit for processing and displaying the electrical pulses, wherein the integrated circuits are in operable communication with the opto-electronic receivers,a microcontroller comprising a program code, programmable memory, and means to display output and communicate with other devices, means of interfacing with the optical source, optical receivers and optical transmitters, to establish and operable communication with the implantable sensor platform,a power supply to power the external unit,one or more optical components providing wavelength selection, transmission or reflection functions, anda miniaturized camera to align the implantable sensor platform with the optical components of the external control unit.

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