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Detection of analytes using reorganization energy

  • US 20080171340A1
  • Filed: 10/30/2007
  • Published: 07/17/2008
  • Est. Priority Date: 06/12/1997
  • Status: Active Grant
First Claim
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1. A method of detecting a target analyte in a test sample comprisinga) adding a target analyte to an electrode comprisingi) a solvent accessible transition metal complex comprising a metal selected from the group consisting of manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver and gold;

  • andii) a binding ligand that will bind said target analyte;

    such that upon binding of said target analyte to said binding ligand, a solvent inhibited transition metal complex is formed; and

    b) measuring a change in E0 of said transition metal complex.

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