Methods and devices for catheter advancement and delivery of substances therethrough

• US 20080172035A1
• Filed: 10/18/2006
• Published: 07/17/2008
• Est. Priority Date: 10/18/2006
• Status: Active Grant

• Current Assignee: Ancora Heart, Inc.
• Original Assignee: Guided Delivery Systems, Inc.
• Inventors: Fabro, Mariel, Im, Karl S., Starksen, Niel F., Serina, Eugene, Meier, Stephen
• Granted Patent: US 8,388,680 B2
• Time in Patent Office: Days
• US Class Current: 604/508
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/0485 Devices or means, e.g. loops, for capturing the suture thread and threading it through an opening of a suturing instrument or needle eyelet
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00783 Valvuloplasty
• CPC Class Codes: A61B 2017/0496 for tensioning sutures
• CPC Class Codes: A61B 2017/06019 by means of a suture-receiving lateral eyelet machined in the needle lateral opening for attaching suture to suture anchor A61B2017/0414
• CPC Class Codes: A61F 2/2466 Delivery devices therefor
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence

Abstract

Methods and devices for successively advancing a plurality of catheters over a guide element to a body tissue are described. In some of the methods, the guide element may be attached to the body tissue, which may be accessible minimally invasively. In certain variations, the guide element may not be detached from the body tissue after the catheters have been advanced over the guide element. The methods may further comprise deploying at least one implant from at least one of the plurality of catheters. In some variations, a method may comprise advancing a first delivery catheter to a first region of a body tissue, deploying a first anchor from the first delivery catheter, where the first anchor is attached to a guide element, proximally withdrawing the first delivery catheter, advancing a second delivery catheter over the guide element, and deploying a second anchor from the second delivery catheter.

Claims

1. A method comprising:

successively advancing a plurality of catheters over a guide element that is attached to a body tissue, wherein the guide element is not detached from the body tissue after the catheters have been advanced over the guide element.

2. The method of claim 1, wherein the body tissue is accessible minimally invasively.

3. The method of claim 1, further comprising deploying at least one implant from at least one of the plurality of catheters.

4. The method of claim 3, wherein the at least one implant is at least one anchor.

5. The method of claim 4, wherein the at least one anchor self-expands and self-secures into a region of the body tissue.

6. The method of claim 3, wherein the at least one implant is at least one electrode.

7. The method of claim 1, wherein the body tissue comprises heart tissue.

8. The method of claim 7, wherein the heart tissue comprises mitral valve tissue.

9. The method of claim 1, wherein at least one of the plurality of catheters is a drug delivery catheter.

10. The method of claim 1, wherein at least one of the plurality of catheters is a locking catheter or a cutting catheter.

11. The method of claim 1, wherein the tether comprises a suture.

12. The method of claim 1, wherein at least one of the plurality of catheters has a proximal section and a distal section, and defines a lumen that is located in the distal section and not in the proximal section.

13. The method of claim 12, wherein the lumen is configured to allow passage of a tether therethrough.

14. A method comprising:

successively advancing a plurality of catheters over a tether, wherein the tether is attached to a body tissue that is accessible minimally invasively.

15. The method of claim 14, further comprising deploying at least one implant from at least one of the plurality of catheters.

16. The method of claim 15, wherein the at least one implant is at least one anchor.

17. The method of claim 16, wherein the at least one anchor self-expands and self-secures into a region of the body tissue.

18. The method of claim 15, wherein the at least one implant is at least one electrode.

19. The method of claim 14, wherein the body tissue comprises heart tissue.

20. The method of claim 19, wherein the heart tissue comprises mitral valve tissue.

21. The method of claim 14, wherein at least one of the plurality of catheters is a drug delivery catheter.

22. The method of claim 14, wherein at least one of the plurality of catheters is a locking catheter or a cutting catheter.

23. The method of claim 14, wherein the tether comprises a suture.

24. The method of claim 14, wherein at least one of the plurality of catheters has a proximal section and a distal section, and defines a lumen that is located in the distal section and not in the proximal section.

25. The method of claim 24, wherein the lumen is configured to allow passage of a tether therethrough.

26. A method comprising:

advancing a first delivery catheter to a first region of a body tissue;

deploying a first anchor from the first delivery catheter, wherein the first anchor is attached to a guide element;

proximally withdrawing the first delivery catheter;

advancing a second delivery catheter over the guide element; and

deploying a second anchor from the second delivery catheter.

27. The method of claim 26, wherein the guide element comprises a tether.

28. The method of claim 27, wherein the tether comprises a suture.

29. The method of claim 28, wherein the suture comprises polyester impregnated with polytetrafluoroethylene.

30. The method of claim 26, wherein the second anchor is slidably coupled to the guide element.

31. The method of claim 30, wherein the second anchor comprises an eyelet, and the second anchor is slidably coupled to the guide element by engaging the guide element with a lasso and proximally withdrawing the lasso through the eyelet.

32. The method of claim 26, wherein the first and second anchors are deployed to different regions of the body tissue.

33. The method of claim 26, wherein the first and second anchors self-expand and self-secure into different regions of the body tissue.

34. The method of claim 26, wherein advancing the first delivery catheter to the first region of the body tissue comprises advancing the first delivery catheter through a tunnel catheter.

35. The method of claim 34, wherein the tunnel catheter comprises a generally tubular member having an opening.

36. The method of claim 35, wherein the opening is positioned on a side wall of the generally tubular member.

37. The method of claim 35, wherein the generally tubular member has a proximal end and a distal end, and the opening is located proximal to the distal end of the generally tubular member.

38. The method of claim 35, wherein advancing the first delivery catheter through the tunnel catheter comprises advancing a portion of the first delivery catheter through the opening in the wall of the generally tubular member.

39. The method of claim 34, further comprising positioning the tunnel catheter at a second region of the body tissue prior to advancing the second delivery catheter over the guide element.

40. The method of claim 34, wherein the tunnel catheter has a proximal portion and a distal portion, and the distal portion of the tunnel catheter is pre-shaped to include at least one curve.

41. The method of claim 26, wherein the method is used to deploy at least three anchors.

42. The method of claim 26, wherein the body tissue is heart tissue.

43. The method of claim 42, wherein the heart tissue comprises mitral valve tissue, where the mitral valve comprises an annulus.

44. The method of claim 43, further comprising cinching the guide element to reduce the circumference of the mitral valve annulus.

45. The method of claim 43, further comprising cinching the guide element to reduce mitral valve regurgitation.

46. The method of claim 43, further comprising cinching the guide element to effect a geometric change in at least one of the mitral valve annulus and tissue surrounding the mitral valve annulus.

47. The method of claim 43, further comprising cinching the guide element to enhance apposition of leaflets of the mitral valve.

48. The method of claim 26, wherein the second delivery catheter has a first lumen and a second lumen.

49. The method of claim 48, wherein the second anchor is releasably coupled to a suture that is disposed within the second lumen.

50. The method of claim 26, wherein the second delivery catheter has a proximal section and a distal section, and the second delivery catheter defines a lumen that is located in the distal section and not in the proximal section.

51. The method of claim 50, wherein the lumen is configured to allow passage of a tether therethrough.

52. A device for stabilizing a catheter with respect to a body tissue, wherein the catheter comprises an expandable member configured to engage against a first portion of tissue in order to stabilize the catheter with respect to a second portion of tissue.

53. The device of claim 52, wherein the expandable member is a low-pressure inflatable balloon and wherein the balloon is made of a compliant material.

54. The device of claim 53, wherein only a portion of the low-pressure balloon is configured to inflate.

55. The device of claim 52, wherein the expandable member is made from a shape memory material.

56. The device of claim 55, wherein the expandable member is made from a nickel titanium alloy.

57. A catheter for advancement along a tether comprising a first and a second lumen, wherein the first and second lumens are positioned adjacent to one another and wherein at least a portion of the first and second lumens is configured to allow the passage of the tether therethrough, and wherein the second lumen is accessible from the first lumen.

58. The catheter of claim 57, wherein the catheter has a proximal section and a distal section, and the second lumen that is located in the distal section and not in the proximal section.

59. The catheter of claim 57, wherein the catheter is a delivery catheter.

60. The catheter of claim 59, wherein the delivery catheter is configured to deliver at least one anchor and wherein the anchor is positioned in the first lumen.

61. The catheter of claim 57, wherein the catheter is a cutting catheter.

62. The catheter of claim 57, wherein the catheter is a termination catheter.