Transmucosal electrical stimulation

• US 20080172102A1
• Filed: 10/31/2007
• Published: 07/17/2008
• Est. Priority Date: 02/20/2004
• Status: Active Grant

• Current Assignee: BrainsGate Ltd.
• Original Assignee: BrainsGate Ltd.
• Inventors: Shalev, Alon
• Granted Patent: US 7,908,000 B2
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0546 Nasal electrodes
• CPC Class Codes: A61N 1/0548 Oral electrodes
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna

Abstract

Apparatus is provided for modifying a property of a brain of a subject, including at least one electrode, configured to be positioned in a vicinity of a mucous membrane of a palate of an oral cavity of the subject. A control unit is configured to drive the electrode to apply an electrical current to the mucous membrane, and to configure the current to be capable of inducing an increase in cerebral blood flow (CBF) of the subject. Other embodiments are also described.

Claims

1-236. -236. (canceled)

237. Apparatus for modifying a property of a brain of a subject, comprising:

at least one electrode, configured to be positioned in a vicinity of a mucous membrane of a palate of an oral cavity of the subject; and

a control unit, configured to drive the electrode to apply an electrical current to the mucous membrane, and to configure the current to be capable of inducing an increase in cerebral blood flow (CBF) of the subject.

238. The apparatus according to claim 237, and comprising an oral appliance, which comprises the at least one electrode.

239. The apparatus according to claim 237, wherein the control unit is configured to configure the current to have a magnitude sufficient to activate a sphenopalatine ganglion (SPG) of the subject via nerve fibers in physical contact with the mucous membrane.

240. The apparatus according to claim 237, wherein the control unit is configured to configure the current to increase the CBF to a magnitude sufficient to treat a condition of the subject.

241. A method for modifying a property of a brain of a subject, comprising:

applying an electrical current to a mucous membrane of a palate of an oral cavity of the subject; and

configuring the current to induce an increase in cerebral blood flow (CBF) of the subject.

242. The method according to claim 241, comprising administering a sedative to the subject in conjunction with applying the current.

243. The method according to claim 241, comprising administering an anesthetic to the subject in conjunction with applying the current.

244. The method according to claim 241, wherein applying the current comprises configuring the current to have a magnitude sufficient to activate a sphenopalatine ganglion (SPG) of the subject via nerve fibers in physical contact with the mucous membrane.

245. The method according to claim 241, wherein applying the current comprises configuring the current to increase the CBF to a magnitude sufficient to treat a condition of the subject.

246. The method according to claim 241, wherein applying the current comprises bringing an oral appliance into contact with the mucous membrane, and applying the current from the oral appliance.