OPTICAL SYSTEMS AND METHODS FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION

  • US 20080188725A1
  • Filed: 02/06/2008
  • Published: 08/07/2008
  • Est. Priority Date: 02/06/2007
  • Status: Active Grant
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First Claim
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1. An optical device for determining blood glucose concentration, comprising:

  • an excitation light source that emits an excitation light signal;

    a fiber optic sensor sized to be positioned within a blood vessel, the sensor being optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits an emission light signal having an intensity related to the blood glucose concentration; and

    a light sensitive module operably coupled to at least the fiber optic sensor, wherein the light sensitive module detects the emission light signal and at least a second light signal, wherein the second light signal is derived from the excitation light source or an optional reference light source.

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