Closed-Loop Method for Controlling Insulin Infusion
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Abstract
A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin.
556 Citations
41 Claims
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1-32. -32. (canceled)
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33. A method for calculating the amount of insulin to be infused into a body of a user, the method comprising:
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obtaining a blood glucose concentration of the user; generating a controller input based on the blood glucose concentration; and generating infusion calculations by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain; wherein the at least one preset controller gain is selected such that the infusion commands generated by the PID controller infuses insulin into the body of the user in response to the glucose concentration at a rate similar to a rate that beta cells would release insulin in an individual with a healthy normally functioning pancreas; and wherein the an automatic blood withdrawal system is used to obtain the blood glucose concentration of the user. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41)
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Specification