TISSUE ABLATION USING PULSE MODULATED RADIO FREQUENCY ENERGY

• US 20080188849A1
• Filed: 11/30/2007
• Published: 08/07/2008
• Est. Priority Date: 12/06/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Young, Kimbolt, Goldberg, S. Nahum
• Granted Patent: US 8,152,801 B2
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/1402 Probes for open surgery
• CPC Class Codes: A61B 18/1485 having a short rigid shaft for accessing the inner body through natural openings
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61B 2018/00726 Duty cycle
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00875 Resistance or impedance

Abstract

Tissue ablation systems and methods are provided. Ablation energy (e.g., radio frequency energy) is delivered to the tissue and a physiological parameter (e.g., impedance and/or temperature) indicative of a change in moisture concentration of the tissue is sensed. The ablation energy is alternately pulsed on and off to generate an energy pulse train, with the ablation energy being pulsed on if the sensed physiological parameter crosses a threshold value indicative of an increase in the moisture concentration, and being pulsed off if the sensed physiological parameter crosses a threshold value indicative of a decrease in the moisture concentration.

Claims

1. A method of treating tissue within a patient, comprising:

delivering ablation energy to the tissue;

sensing a physiological parameter indicative of change in moisture concentration of the tissue; and

alternately pulsing the ablation energy on and off to generate an energy pulse train, wherein the ablation energy is pulsed on if the sensed physiological parameter crosses a threshold value indicative of an increase in the moisture concentration, and is pulsed off if the sensed physiological parameter crosses a threshold value indicative of a decrease in the moisture concentration.

2. The method of claim 1, wherein the physiological parameter is one or more of a temperature and an impedance.

3. The method of claim 1, further comprising amplitude modulating the ablation energy based on a width of a pulse within the energy pulse train.

4. The method of claim 3, wherein the amplitude modulation of the ablation energy comprises decreasing the amplitude of the ablation energy if the width of the pulse decreases below a threshold value.

5. The method of claim 1, wherein the energy pulse train comprises pulses having a width equal to or greater than 1 second.

6. The method of claim 1, wherein the energy pulse train comprises pulses having differing widths.

7. The method of claim 1, wherein the energy pulse train comprises pulses that gradually decrease in amplitude.

8. The method of claim 1, wherein the energy pulse train comprises sets of pulses, each pulse set including pulses having differing widths of the same amplitude, the pulse sets gradually decreasing in amplitude.

9. The method of claim 1, wherein the ablation energy comprises radio frequency (RF) ablation energy.

10. A method of treating tissue within a patient, comprising:

delivering ablation energy to the tissue;

sensing a change in a physiological parameter of the tissue; and

alternately pulsing the ablation energy on and off to generate an energy pulse train, wherein the ablation energy is pulsed on when the sensed physiological parameter drops below a first one or more threshold levels, and is pulsed off when the sensed physiological parameter rises above a second one or more threshold levels.

11. The method of claim 10, wherein the physiological parameter is one or more of a temperature and an impedance.

12. The method of claim 10, further comprising amplitude modulating the ablation energy based on a width of a pulse within the energy pulse train.

13. The method of claim 12, wherein the amplitude modulation of the ablation energy comprises decreasing the amplitude of the ablation energy if the width of the pulse decreases below a threshold value.

14. The method of claim 10, wherein the energy pulse train comprises pulses having a width equal to or greater than 1 second.

15. The method of claim 10, wherein the energy pulse train comprises pulses having differing widths.

16. The method of claim 10, wherein the energy pulse train comprises pulses that gradually decrease in amplitude.

17. The method of claim 10, wherein the energy pulse train comprises sets of pulses, each pulse set including pulses having differing widths of the same amplitude, the pulse sets gradually decreasing in amplitude.

18. The method of claim 10, wherein the first one or more threshold values comprises a first plurality of threshold values that differ from each other, and the second one or more threshold values comprises a second plurality of threshold values that differ from each other.

19. The method of claim 18, wherein the first plurality of threshold values gradually increase, and the second plurality of threshold values gradually increase.

20. The method of claim 10, wherein the ablation energy comprises radio frequency (RF) ablation energy.

21. An ablation energy generator, comprising:

an energy source for outputting ablation energy; and

control circuitry configured for receiving a sensed physiological parameter indicative of change in moisture concentration of the tissue, and for alternately pulsing the ablation energy on and off to generate an energy pulse train, wherein the ablation energy is pulsed on if the sensed physiological parameter crosses a threshold value indicative of an increase in the moisture concentration, and is pulsed off if the sensed physiological parameter crosses a threshold value indicative of a decrease in the moisture concentration.

22. The ablation energy generator of claim 21, wherein the physiological parameter is one or more of a temperature and an impedance.

23. The ablation energy generator of claim 21, wherein the control circuitry is further configured for amplitude modulating the ablation energy based on a width of a pulse within the energy pulse train.

24. The ablation energy generator of claim 23, wherein the control circuitry is configured for amplitude modulating the ablation energy by decreasing the amplitude of the ablation energy if the width of the pulse decreases below a threshold value.

25. The ablation energy generator of claim 21, wherein the control circuitry includes a controller configured for generating a trigger-on signal when the sensed physiological parameter crosses the threshold value indicative of an increase in the moisture concentration, and generating a trigger-off signal when the sensed physiological parameter crosses the threshold value indicative of a decrease in the moisture concentration, and a pulse modulator configured for pulsing the ablation energy on in response to the trigger-on signal, and pulsing the ablation energy off in response to the trigger-off signal.

26. The ablation energy generator of claim 23, wherein the controller is configured for generating an amplitude reduction signal if a pulse within the energy pulse train is below a threshold value, and wherein the control circuitry further comprises an amplitude modulator configured for decreasing the amplitude of the ablation energy in response to the amplitude reduction signal.

27. The ablation energy generator of claim 21, wherein the energy pulse train comprises pulses having a width equal to or greater than 1 second.

28. The ablation energy generator of claim 21, wherein the energy pulse train comprises pulses having differing widths.

29. The ablation energy generator of claim 21, wherein the energy pulse train comprises pulses that gradually decreases in amplitude.

30. The ablation energy generator of claim 21, wherein the energy pulse train comprises sets of pulses, each pulse set including pulses having differing widths of the same amplitude, the pulse sets gradually decreasing in amplitude.

31. The ablation energy generator of claim 21, wherein the energy source is a radio frequency (RF) energy source.

32. An ablation energy generator, comprising:

an energy source for outputting ablation energy; and

control circuitry configured for receiving a sensed physiological parameter, and for alternately pulsing the ablation energy on and off to generate an energy pulse train, wherein the ablation energy is pulsed on when the sensed physiological parameter drops below a first one or more threshold levels, and is pulsed off when the sensed physiological parameter rises above a second one or more threshold levels.

33. The ablation energy generator of claim 32, wherein the physiological parameter is one or more of a temperature and an impedance.

34. The ablation energy generator of claim 32, wherein the control circuitry includes a controller configured for generating a trigger-on signal when the sensed physiological parameter drops below the first threshold value, and for generating a trigger-off signal when the sensed physiological parameter rises above the second threshold value, and a pulse modulator configured for pulsing the ablation energy on in response to the trigger-on signal, and pulsing the ablation energy off in response to the trigger-off signal.

35. The ablation energy generator of claim 34, wherein the controller is configured for generating an amplitude reduction signal if a pulse within the energy pulse train is below a threshold value, and wherein the control circuitry further comprises an amplitude modulator configured for decreasing the amplitude of the ablation energy in response to the amplitude reduction signal.

36. The ablation energy generator of claim 32, wherein the energy pulse train comprises pulses having a width equal to or greater than 1 second.

37. The ablation energy generator of claim 32, wherein the energy pulse train comprises pulses having differing widths.

38. The ablation energy generator of claim 32, wherein the energy pulse train comprises pulses that gradually decreases in amplitude.

39. The ablation energy generator of claim 32, wherein the energy pulse train comprises sets of pulses, each pulse set including pulses having differing widths of the same amplitude, the pulse sets gradually decreasing in amplitude.

40. The ablation energy generator of claim 32, wherein the first one or more threshold values comprises a first plurality of threshold values that differ from each other, and the second one or more threshold values comprises a second plurality of threshold values that differ from each other.

41. The ablation energy generator of claim 40, wherein the first plurality of threshold values gradually increase, and the second plurality of threshold values gradually increase.

42. The ablation energy generator of claim 32, wherein the energy source is a radio frequency (RF) energy source.