ANALYTE SENSOR

• US 20080200788A1
• Filed: 03/25/2008
• Published: 08/21/2008
• Est. Priority Date: 10/04/2006
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: Dexcorn Incorporated
• Inventors: Brister, Mark, Leach, Jacob S., Swanson, Vance
• Application Number:
  US12/055,149
• Publication Number:
  US 20080200788A1
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.

Claims

1. A method for continuously measuring an analyte in an artery of a host in vivo, the method comprising:

coupling a continuous analyte sensor with an arterial catheter system applied to a host, wherein the sensor is configured to generate an analyte-related signal associated with an analyte in a sample, and wherein the arterial catheter system comprises an arterial catheter, an infusion fluid, and a pressure system configured to perform at least one of increasing an amount of pressure applied to the infusion fluid and reducing an amount of pressure applied to the infusion fluid;

reducing the amount of pressure applied to the infusion fluid, such that a sample of arterial blood contacts the sensor; and

generating the analyte-related signal with the sensor.

2. The method of claim 1, further comprising reinfusing the sample into the host.

3. The method of claim 2, wherein the reinfusing step comprises increasing the amount of pressure applied to the infusion fluid.

4. The method of claim 1, wherein the generating step further comprises generating a second signal with the sensor, wherein sensor comprises a first working electrode configured to generate a first signal comprising an analyte-related signal component and a non-analyte-related signal component and the second working electrode is configured to generate the second signal comprising the non-analyte-related signal component.

5. The method of claim 4, further comprising processing the first signal and second signal to provide a processed signal substantially without a signal component due to the non-analyte-related signal component.

6. The method of claim 4, further comprising processing the first signal and second signal to provide a scaling factor.

7. The method of claim 1, further comprising monitoring an arterial blood pressure of the host using a pressure transducer.

8. The method of claim 1, wherein the coupling step comprises coupling the sensor to the arterial catheter.

9. The method of claim 1, wherein the coupling step comprises inserting the sensor into a lumen of the catheter, wherein the catheter comprises at least one lumen.

10. The method of claim 1, wherein the generating step further comprises generating a reference signal associated with a reference analyte in the sample, wherein the sensor further comprises a reference sensor configured to generate the reference signal.

11. The method of claim 1, further comprising processing the analyte-related signal to provide an analyte value, wherein the sensor further comprises a processor module configured to process the signal.

12. The method of claim 1, further comprising calibrating the signal.

13. A system for continuously measuring an analyte in an artery of a host in vivo, the system comprising:

an arterial infusion system configured and arranged to meter at least one of flow of a fluid into an artery of a host and flow of a fluid out of an artery of a host, the arterial infusion system comprising an arterial catheter, an infusion fluid, and a pressure system configured to perform at least one of increasing an amount of pressure applied to the infusion fluid and reducing an amount of pressure applied to the infusion fluid, wherein when the infusion system is applied to the host, the pressure system is further configured to infuse the infusion fluid, withdraw a blood sample, and reinfuse the withdrawn blood sample into the host; and

a continuous analyte sensor configured to couple with the arterial infusion system, configured to contact a sample of the host, and configured to generate a first signal associated with an analyte in the sample.

14. The system of claim 13, wherein the sensor comprises a first working electrode and a second working electrode, wherein the first working electrode is configured to generate the first signal comprising an analyte-related signal component and a non-analyte-related signal component, and wherein the second working electrode is configured to generate a second signal comprising the non-analyte related signal component.

15. The system of claim 14, further comprising a processor module configured to process the first signal and second signal to provide a scaling factor.

16. The system of claim 15, wherein the processor module is further configured to calibrate the first signal using the scaling factor.

17. The system of claim 14, further comprising a reference sensor configured to generate are reference signal associated with a reference analyte in the sample.

18. The system of claim 17, wherein the processor module is further configured to calibrate the first signal using the scaling factor.

19. The system of claim 13, further comprising a processor module configured to process the first signal.

20. The system of claim 13, further comprising a processor module configured to calibrate the sensor.

21. The system of claim 13, further comprising electronics configured and arranged to regulate the pressure system.