Inhibition of pathogens by probiotic bacteria

• US 20080206214A1
• Filed: 02/13/2007
• Published: 08/28/2008
• Est. Priority Date: 11/08/1999
• Status: Active Grant

• Current Assignee: Ganeden Biotech, Inc. (Kerry Group PLC)
• Original Assignee: Ganeden Biotech, Inc. (Kerry Group PLC)
• Inventors: Farmer, Sean
• Granted Patent: US 7,713,726 B2
• Time in Patent Office: Days
• US Class Current: 424/93.46
• CPC Class Codes: A61K 35/742 Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: Y10S 435/832 Bacillus

Abstract

Compositions containing a lactic acid-producing bacterial strain, e.g., Bacillus coagulans for inhibition of pathogenic bacterial infections. Spores or extracellular products produced by the bacterial strains are also useful as inhibitory agents.

Claims

1. A composition comprising an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).

2. The composition of claim 1, wherein said strain produces lactic acid and has an optimal growth temperature of in the range of 25-35°

C.

3. The composition of claim 1, wherein said strain produces L(+) dextrorotatory lactic acid and produces spores resistant to temperatures of up to approximately 90°

C.

4. An extracellular product derived from the composition of claim 1.

5. A food or food supplement comprising the composition of claims 1.

9. A method of inhibiting a pathogenic bacterial infection, comprising contacting an infected site with the composition of claim 1.

6. A method comprising administering to the gastrointestinal tract of a mammal a composition comprising an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).

7. The method of claim 6, wherein said composition is administered orally, buccally topically, vaginally, nasally, ocularly, or otically.

8. The method of claim 6, wherein said composition is administered in a food or as a food supplement.

10. A composition comprising poultry feed and an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).

11. A method of inhibiting an infection, comprising administering to the gastrointestinal tract of poultry a composition comprising poultry feed and an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).

12. A composition comprising poultry feed and an isolated Bacillus coagulans GBI-20 strain (ATCC Designation Number PTA-6085).

13. A method of inhibiting an infection, comprising administering to the gastrointestinal tract of poultry a composition comprising poultry feed and an isolated Bacillus coagulans GBI-20 strain (ATCC Designation Number PTA-6085).

14. A composition comprising poultry feed and an isolated Bacillus coagulans GBI-40 strain (ATCC Designation Number PTA-6087).

15. A method of inhibiting an infection, comprising administering to the gastrointestinal tract of poultry a composition comprising poultry feed and an isolated Bacillus coagulans GBI-40 strain (ATCC Designation Number PTA-6087).