METHOD OF DETERMINING ANALYTE CONCENTRATION IN A SAMPLE USING INFRARED TRANSMISSION DATA

• US 20080212071A1
• Filed: 08/20/2007
• Published: 09/04/2008
• Est. Priority Date: 04/15/2003
• Status: Active Grant

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Braig, James R., Sterling, Bernhard B., Goldberger, Daniel S., Gaffney, Robert D., Hartstein, Philp C.
• Granted Patent: US 7,593,108 B2
• Time in Patent Office: Days
• US Class Current: 356/39
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: G01N 21/03 Cuvette constructions
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/35 using infrared light G01N21/39 takes precedence

Abstract

A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.

Claims

1. A method of determining an optical pathlength of a sample comprising water and a blood protein, the method comprising:

measuring an optical absorption of the sample at an isosbestic wavelength for water and a blood protein;

using the optical absorption to calculate-independent of water or blood protein concentration—

the optical pathlength of the sample; and

providing the optical pathlength to a user.

2. The method of claim 1, wherein the blood protein comprises hemoglobin.

3. The method of claim 1, wherein the blood protein comprises albumin.

4. The method of claim 1, wherein the blood protein comprises globulin.

5. The method of claim 1, wherein the blood protein comprises ferritin.

6. The method of claim 1, wherein the blood protein is a whole blood protein.

7. The method of claim 1, wherein the sample comprises blood plasma.

8. The method of claim 1, wherein the sample comprises whole blood.

9. The method of claim 8, further comprising separating the sample into plasma and other constituents.