Amphiphilic or lipophilic polar functionalized fullerenes and their uses
First Claim
Patent Images
1. A synthetically modified fullerene molecule having the formula
Zm-F—
- Yn;
wherein F is fullerene of formula Cp or X@Cp, the fullerene having two opposing poles and an equatorial region;
Z and Y are positioned near respective opposite poles of Cp;
m=1-5 and Z is a hydrophilic, lipophilic, or amphiphilic chemical moiety;
n=1-5 and Y is a lipophilic chemical moiety;
p=60-120 and p is an even number; and
X, if present, represents one or more metal atoms within the fullerene (F), optionally in the form of a trinitride of formula Gi=1−
3Hk=3−
iN in which G and H are metal atoms.
8 Assignments
0 Petitions
Accused Products
Abstract
Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
16 Citations
31 Claims
-
1. A synthetically modified fullerene molecule having the formula
Zm-F—- Yn;
wherein F is fullerene of formula Cp or X@Cp, the fullerene having two opposing poles and an equatorial region; Z and Y are positioned near respective opposite poles of Cp; m=1-5 and Z is a hydrophilic, lipophilic, or amphiphilic chemical moiety; n=1-5 and Y is a lipophilic chemical moiety; p=60-120 and p is an even number; and X, if present, represents one or more metal atoms within the fullerene (F), optionally in the form of a trinitride of formula Gi=1−
3Hk=3−
iN in which G and H are metal atoms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- Yn;
-
20. A synthetic fullerene molecule having the formula Z(C70)Y;
- wherein Y is a lipophilic moiety covalently connected to C70, optionally through a linking group, at or near a pole thereof, and wherein Z is a lipophilic moiety, amphiphilic moiety, or a hydrophilic moiety covalently connected to C70, optionally through a linking group, at or near a pole opposite to said Y; and
, wherein said lipophilic moiety Y is capable of anchoring the synthetic fullerene molecule to a lipid membrane. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
- wherein Y is a lipophilic moiety covalently connected to C70, optionally through a linking group, at or near a pole thereof, and wherein Z is a lipophilic moiety, amphiphilic moiety, or a hydrophilic moiety covalently connected to C70, optionally through a linking group, at or near a pole opposite to said Y; and
Specification