Water dispersible policosanol cyclodextrin complex and method of its production
First Claim
1. A water dispersible complex, which comprises:
- water dispersible policosanol cyclodextrin complex in a molar ratio of cyclodextrin to policosanol ranging from about 0.5;
1 to about 10;
1.
1 Assignment
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Accused Products
Abstract
Disclosed is a formulation of policosanol with natural cyclodextrins resulting in a water dispersible form of policosanol. The disclosed process provides an economical commercial method for making the policosanol complex. The complex is suitable for incorporation into oral dosage forms and also in functional foods. One aspect of the present disclosure is a process for making a water dispersible policosanol cyclodextrin complex for animal ingestion. This method includes preparing a policosanol cyclodextrin complex and administering said complex to an animal. The preferred animal is a human with the route of administration being oral ingestion. The form of the complex for ingestion can be a hard gelatin capsule, tablet or wafers, which may contain other ingredients, both active and inactive. The complex also can be further formulated with excipients suitable for soft gelatin capsules, such as, for example, vegetable oils, waxes, lecithin, and surfactants such as Tween-80.
1 Citation
20 Claims
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1. A water dispersible complex, which comprises:
water dispersible policosanol cyclodextrin complex in a molar ratio of cyclodextrin to policosanol ranging from about 0.5;
1 to about 10;
1.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for making a water dispersible complex, which comprises the steps of:
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(a) forming a heated oily solution of policosanol and a surfactant; (b) forming a heated aqueous solution of a cyclodextrin; (c) mixing said oily solution under agitation to aqueous cyclodextrin solution to form a mixture; and (d) cooling said mixture to form a complex precipitate. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification