System and Method for Processing Chemical Substances, Computer Program for Controlling Such System, and a Corresponding Computer-Readable Storage Medium

• US 20080233653A1
• Filed: 06/01/2006
• Published: 09/25/2008
• Est. Priority Date: 06/17/2005
• Status: Abandoned Application

• Current Assignee: Eckert & Ziegler Eurotope GmbH (Eckert & Ziegler AG)
• Original Assignee: Eckert & Ziegler Eurotope GmbH (Eckert & Ziegler AG)
• Inventors: Burde, Thomas, Knopp, Roger, Hess, Andre, Steinke, Frank
• Application Number:
  US11/817,840
• Publication Number:
  US 20080233653A1
• Time in Patent Office: Days
• US Class Current: 436/43
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: G01N 2030/8881 Modular construction, specially adapted therefor
• CPC Class Codes: G01N 2035/00326 Analysers with modular structure
• CPC Class Codes: G01N 30/88 Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
• CPC Class Codes: G01N 35/00871 Communications between instruments or with remote terminals
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

The invention is directed to a system and a method for processing chemical substances, a computer program for controlling such system, and a corresponding computer-readable storage medium, which can be used, in particular, to flexibly adapt synthesis devices, in particular for radioactive chemicals or radioactive pharmaceutical products, to different process flows and to make the synthesis devices usable for research and routine operation.

To this end, a system for processing chemical substances in a laboratory setting is proposed, wherein the system includes components for carrying out basic chemical processing operations. The components can be modularly combined according to presettable sequences of process steps for processing chemical substances and have matching modular dimensions. The components can also be implemented as stackable, self-supporting boxes.

Claims

1-29. -29. (canceled)

30. System for processing chemical substances in a laboratory environment comprising:

components for performing chemical processing operations, wherein the components are combinable in modular form according to a presettable sequence of process steps for processing at least a first chemical substance, wherein the processing includes synthesis of at least a second chemical substance and at least partially automatically controlling at least one of the components, and

wherein the components have matching modular dimensions and are implemented as stackable, self-supporting boxes.

31. System according to claim 30,

characterized in that

at least one of the first and chemical substances is a radioactive substance.

32. System according to claim 30,

characterized in that

the second chemical substance is at least one of a pharmaceutical product and a diagnostic product.

33. System according to claim 30,

characterized in that the

components include a component for filling and a component for performing a basic chemical processing operation.

34. System according to claim 30,

characterized in that

the chemical processing operations comprise at least one of

transport of vials/syringes,

filtration,

heating/cooling,

filling,

emptying,

dosing,

dispensing,

mixing,

diluting,

stirring,

agitation,

extraction,

ion exchange,

chromatography, in particular HPLC,

detection of product properties,

evaporating,

boiling,

rinsing and cleaning, and

generation of underpressure or overpressure.

35. System according to claim 30,

characterized in that the components are combinable to perform at least one of the process steps of:

sterile filtration,

determination of the integrity of a sterile filter,

labeling,

packaging and

filling.

36. System according to claim 30,

characterized in that

the components are implemented as at least one of a

valve module,

vial module,

vial transport module,

vial agitation module,

cartridge module,

distribution module,

reactor module,

heater module,

dosing/dispensing module, for example a syringe module,

HPLC unit,

cold-trap module,

vacuum system

overpressure system,

filling module, and

analytic device.

37. System according to claim 30,

characterized in that the components are in a modular combination such that:

(i) a first of the components is exchangeable with a second of the components for replacing a process step in the sequence of process steps;

or (ii) a third of the components is insertable into the combination for adding a process step to the sequence of process steps.

38. System according to claim 37,

characterized in that the

components are connectable in a linear arrangement via an intelligent bus system.

39. System according to claim 38,

characterized in that the

components are combinable with one another at any location of a line.

40. System according to claim 30,

characterized in that the sequence of process steps includes reactor cooling and a first of the components performs the reactor cooling without using liquid nitrogen.

41. System according to claim 38,

characterized in that

the intelligent bus system automatically recognizes the connected components.

42. System according to claim 30,

characterized in that

at least one of the components are combinable with a single-use element.

43. Method for processing chemical substances in a laboratory environment by using components for performing chemical processing operations comprising;

providing components implemented as stackable, self-supporting boxes and having matched modular dimensions, wherein the components are modularly combinable;

configuring the components into a modular combination according to a preset sequence of process steps for processing at least a first chemical substance; and

processing the at least first chemical substance with the modularly combined components, wherein the processing is at least partially automatically controlled and synthesizes a second chemical substance.

44. Method according to claim 43,

characterized in that the configuring and the automatic controlling are performed under a common software user interface.

45. Method according to claim 43,

characterized in that

at least a first of the components is employed in a sterile operation in the processing, and the first component is at least one of a sterilized single-use component and a reusable component.

46. Method according to claim 43,

characterized in that the automatic controlling is performed by a computer program encoded on a computer readable medium, and wherein the computer program uses a uniform database stored in a memory for the configuring of the components.

47. Method according to claim 43,

characterized in that the automatic controlling is performed by a computer program encoded on a computer readable medium and provides a mode for manual control of the processing.

48. Method according to claim 43,

characterized in that at least one of the components is combined with a filling module and the processing includes at least one of filling of vial geometries and syringes by using an adapter.

49. A computer-readable medium encoded with a computer program executable by a computer, wherein the program includes steps of a process for processing at least a first chemical substance in a laboratory environment by using components for performing chemical processing operations, wherein the components are combinable in a modular combination and are implementable as stackable, self-supporting boxes having matched modular dimensions, wherein the process comprises;

configuring the components in a modular combination according to a preset sequence of process steps for processing at least a first chemical substance; and

processing the at least first chemical substance with the modularly combined components, wherein the processing is at least partially automatically controlled by the computer and synthesizes a second chemical substance.

50. The method of claim 49, wherein the computer program is downloaded from an electronic data network.

51. The method of claim 50, wherein the network is the Internet.

52. The method of claim 50, wherein the medium is connected to the data network.