METHOD AND APPARATUS FOR SENSING RESPIRATORY ACTIVITIES USING SENSOR IN LYMPHATIC SYSTEM

• US 20080234556A1
• Filed: 03/20/2007
• Published: 09/25/2008
• Est. Priority Date: 03/20/2007
• Status: Abandoned Application

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Shuros, Allan C., Brooke, M. Jason, Pu, Yachuan
• Application Number:
  US11/688,380
• Publication Number:
  US 20080234556A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/113 occurring during breathing
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A respiratory monitoring system includes an implantable lymphatic sensor configured to be placed in a lymphatic vessel, such as the thoracic duct or a vessel branching from the thoracic duct, near the diaphragm. The implantable lymphatic sensor senses a signal indicative of respiratory activities. Examples of the signal include a diaphragmatic activity signal indicative of movement of the diaphragm and a transthoracic impedance signal indicative of pulmonary volume. In one embodiment, the respiratory monitoring system is incorporated into a cardiac rhythm management system that controls cardiac therapy delivery using the signal sensed by the implantable lymphatic sensor.

Claims

1. A system for use in a body having a diaphragm and a lymphatic vessel, the system comprising:

a lymphatic sensor assembly configured to be implanted in the lymphatic vessel, the lymphatic sensor assembly including;

a lymphatic sensor configured to sense a lymphatic sensor signal indicative of respiratory activities; and

a lymphatic sensor base connected to the lymphatic sensor and configured to allow the lymphatic sensor assembly to be implanted in the lymphatic vessel; and

a sensor signal processor communicatively coupled to the lymphatic sensor, the sensor signal processor including;

a sensor signal input configured to receive the lymphatic sensor signal;

a respiration monitor coupled to the sensor signal input and configured to produce a respiratory signal indicative of the respiratory activities by processing the lymphatic sensor signal; and

a respiratory parameter generator coupled to the respiration monitor and configured to produce one or more respiratory parameters using the respiratory signal.

2. The system of claim 1, wherein the lymphatic sensor comprises a diaphragmatic activity sensor configured to sense a diaphragmatic activity signal indicative of movement of the diaphragm.

3. The system of claim 2, wherein the diaphragmatic activity sensor comprises an accelerometer configured to sense an accelerometer signal indicative of the movement of the diaphragm.

4. The system of claim 3, wherein the sensor signal processor comprises a posture monitor configured to produce a posture signal indicative of a posture of the body using the accelerometer signal.

5. The system of claim 3, wherein the sensor signal processor comprises an activity monitor configured to produce a gross activity signal indicative of a level of gross physical activity of the body using the accelerometer signal.

6. The system of claim 2, wherein the diaphragmatic activity sensor comprises a strain gauge configured to sense a strain gauge signal indicative of the movement of the diaphragm.

7. The system of claim 2, comprising an implantable medical device including the sensor signal processor and an implant telemetry circuit coupled to the sensor signal processor and configured to receive the diaphragmatic activity signal from the lymphatic sensor assembly via a wireless communication link, and wherein the lymphatic sensor assembly comprises a sensor telemetry circuit coupled to the diaphragmatic activity sensor and configured to transmit the sensed diaphragmatic activity signal to the implantable medical device via the wireless telemetry link.

8. The system of claim 1, wherein the lymphatic sensor comprises an impedance sensing electrode configured to sense a transthoracic impedance signal indicative of pulmonary volume.

9. The system of claim 8, wherein the sensor signal processor comprises a pulmonary edema detector configured to detect pulmonary edema using the transthoracic impedance signal.

10. The system of claim 1, wherein the lymphatic sensor base comprises a fixation mechanism configured to stabilize the lymphatic sensor assembly in the lymphatic vessel.

11. The system of claim 10, wherein the lymphatic sensor base comprises a stent configured to be placed in the lymphatic vessel.

12. The system of claim 10, wherein the lymphatic sensor base comprises a balloon configured to be placed in the lymphatic vessel.

13. The system of claim 1, comprising:

an implantable medical device including the sensor signal processor; and

an implantable transluminal lead including;

a proximal end configured to be connected to the implantable medical device;

a distal end; and

an elongate body coupled between the proximal end and a distal end, the elongate body having a distal portion connected to the distal end and configured to be placed in the lymphatic vessel,

wherein one or more of the distal end and the distal portion include the lymphatic sensor assembly.

14. The system of claim 1, comprising:

a therapy delivery device configured to deliver one or more therapies to the body; and

a therapy controller configured to control the delivery of one or more therapies using the one or more respiratory parameters.

15. The system of claim 14, wherein the therapy controller comprises a feedback controller adapted to adjust one or more therapy parameters of the one or more therapies using the one or more respiratory parameters as input.

16. The system of claim 14, wherein the sensor signal processor comprises a respiratory disorder detector configured to detect one or more respiratory disorders using the one or more respiratory parameters, and wherein the therapy controller is configured to adjust one or more therapy parameters of the one or more therapies in response to the detection of each of the one or more respiratory disorders.

17. A method for monitoring respiratory activities in a body having a diaphragm and a lymphatic vessel, the method comprising:

sensing a lymphatic sensor signal using a lymphatic sensor implanted in the lymphatic vessel, the lymphatic sensor signal indicative of respiratory activities;

producing a respiratory signal indicative of the respiratory activities using the lymphatic sensor signal; and

producing one or more respiratory parameters using the respiratory signal.

18. The method of claim 17, wherein sensing the lymphatic sensor signal using the lymphatic sensor comprises sensing a diaphragmatic activity signal indicative of movement of the diaphragm using an activity sensor.

19. The method of claim 18, wherein sensing the diaphragmatic activity signal indicative of movement of the diaphragm using the activity sensor comprises sensing an accelerometer signal indicative of the movement of the diaphragm using an accelerometer.

20. The method of claim 19, comprising producing one or more of an activity signal indicative of a level of gross physical activity of the body and a posture signal indicative of posture of the body using the accelerometer signal.

21. The method of claim 20, comprising:

delivering one or more therapies to the body; and

controlling delivery of the one or more therapies using the respiratory signal and the one or more of the activity signal and the posture signal.

22. The method of claim 17, wherein sensing the lymphatic sensor signal using the lymphatic sensor comprises sensing a transthoracic impedance signal indicative of pulmonary volume using an impedance sensing electrode.

23. The method of claim 17, comprising:

delivering one or more therapies to the body;

controlling delivery of the one or more therapies using one or more therapy parameters; and

adjusting the one or more therapy parameters using the one or more respiratory parameters.

24. The method of claim 23, comprising detecting one or more respiratory disorders using the one or more respiratory parameters, and wherein adjusting the one or more therapy parameters comprises adjusting the one or more therapy parameters in response to the detection of each of the one or more respiratory disorders.

25. The method of claim 24, wherein delivering the one or more therapies comprises delivering neurostimulation, and adjusting the one or more therapy parameters comprises adjusting one or more neurostimulation parameters in response to the detection of each of the one or more respiratory disorders.

26. The method of claim 23, wherein delivering the one or more therapies comprises delivering cardiac pacing pulses, and adjusting the one or more therapy parameters comprises adjusting one or more pacing parameters.

27. The method of claim 26, comprising detecting artificial stimulation of the phrenic nerve using the respiratory signal, and wherein adjusting the one or more pacing parameters comprises adjusting the one or more pacing parameters in response to the detection of the artificial stimulation of the phrenic nerve to prevent the cardiac pacing pulses from activating the phrenic nerve.

28. The method of claim 26, wherein producing the one or more respiratory parameters comprises producing a respiratory rate, and wherein adjusting the one or more pacing parameters comprises adjusting the one or more pacing parameters using the respiratory rate.

29. The method of claim 23, wherein delivering the one or more therapies comprises delivering one or more of a cardiac pacing therapy, a neurostimulation therapy, a drug therapy, and a biologic therapy.