Pharmaceutical Composition
5 Assignments
0 Petitions
Accused Products
Abstract
A pharmaceutical composition comprising: (A) an androgen; (B) a cyclic enhancer of the type used in the compositions and methods claimed by U.S. Pat. No. 5,023,252 to Hsieh; and (C) a thickening agent; including, for example, a composition in which the cyclic enhancer is a macrocyclic ester or a macrocyclic ketone; the use of the composition to treat a condition, for example, male hypogonadism, in a patient by applying the composition to the membrane of the patient; and a method for making the composition.
49 Citations
77 Claims
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1-52. -52. (canceled)
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53. A method for delivering at least one androgen to a patient in need thereof in which there is maintained on a membrane of the patient for a period of time sufficient for delivery of the desired amount of androgen to the patient'"'"'s body through said membrane a composition comprising:
- (A) about 0.01 to about 15 wt. % of an androgen;
(B) about 0.01 to about 25 wt. % of a Hsieh enhancer; and
(C) about 0.1 to about 10 wt. % of a thickening agent;
wherein the androgen is selected from the group consisting of testosterone, dihydrotestosterone (DHT), and precursors, congeners, salts, complexes, and analogs of testosterone and DHT. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
- (A) about 0.01 to about 15 wt. % of an androgen;
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69. A method which is useful for maintaining an effective concentration of testosterone in the blood serum of a male for treating hypogonadism and which comprises transdermally delivering to the male by applying to the skin of the male a composition which is in the form of a topical gel, which has a viscosity of about 2000 to about 6000 cps and a pH of about 4 to 8, and which comprises:
- (A) about 0.1 to about 5 wt. % of testosterone;
(B) about 0.5 to about 15 wt. % of oxacyclohexadecan-2-one; and
about 1 to 6 wt. % of a thickening agent; and
wherein said composition is maintained on said skin for a period of time sufficient for delivery of the testosterone to the body of the male. - View Dependent Claims (70, 71, 72, 73, 74, 75, 76, 77)
- (A) about 0.1 to about 5 wt. % of testosterone;
Specification