INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR

• US 20080287764A1
• Filed: 07/29/2008
• Published: 11/20/2008
• Est. Priority Date: 11/19/2003
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brauker, James H., Simpson, Peter C., Neale, Paul V., Rasdal, Andrew
• Granted Patent: US 8,282,550 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 2560/0456 Apparatus provided with a docking unit
• CPC Class Codes: A61B 2562/247 Hygienic covers, i.e. for covering the sensor or apparatus during use
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host'"'"'s glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.

Claims

1. An integrated system comprising:

a continuous glucose sensor configured to continuously measure a glucose concentration in a host, wherein the continuous glucose sensor generates continuous glucose sensor data associated with the glucose concentration in the host; and

a receiver unit comprising a single point glucose monitor physically attached thereto, wherein the receiver unit is in data communication with the continuous glucose sensor and configured to receive and calibrate the continuous glucose sensor data based on a value obtained from the single point glucose monitor, and wherein the receiver unit is further in data communication with an insulin delivery device and configured to process and transmit insulin administration information to the insulin delivery device based at least in part on a rate of change of the sensor data or a directional trend associated with the continuous glucose sensor data.

2. The system of claim 1, wherein each of the continuous glucose sensor and the single point glucose monitor comprise a sensing membrane comprising an enzyme domain, and wherein the enzyme domain of the sensing membrane of the continuous glucose sensor and the enzyme domain of the sensing membrane of the single point glucose monitor are substantially the same.

3. The system of claim 1, wherein the single point glucose monitor is configured to receive a single use test strip.

4. The system of claim 1, wherein the receiver unit comprises programming to control time and/or amount of administration of insulin to the host.

5. The system of claim 1, further comprising an insulin delivery device.

6. The system of claim 5, wherein the insulin delivery device comprises an insulin pump, and wherein the receiver unit is further configured to process and transmit insulin administration information to the insulin delivery device based at least in part the glucose concentration measured by the continuous glucose sensor.

7. The system of claim 1, wherein the programming to control time and/or amount of administration of insulin to the host comprises programming to control administration of insulin to the host based at least in part on the rate of change of the continuous glucose sensor data.

8. The system of claim 1, wherein the programming to control time and/or amount of administration of insulin to the host comprises programming to control administration of insulin to the host based at least in part on the directional trend of the continuous glucose sensor data.

9. The system of claim 1, wherein the receiver unit is configured to monitor the continuous glucose sensor data to adaptively determine a time for requesting a biological sample.

10. The system of claim 1, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to prompt the user, via the user interface, to provide a biological sample to the single point glucose monitor at predetermined intervals.

11. The system of claim 1, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to prompt the user, via the user interface, to provide a biological sample to the single point glucose monitor based upon one or more events.

12. The system of claim 11, wherein the one or more events comprise one or more events selected from the group consisting of meals, exercise, large excursions in glucose levels, and faulty or interrupted data readings.

13. The system of claim 1, wherein receiver unit is configured to compare the value obtained from the single point glucose monitor with one or more acceptability parameters.

14. The system of claim 1, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to display the value obtained from the single point glucose monitor and the continuous glucose sensor data from the continuous glucose sensor on the user interface.

15. The system of claim 1, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to simultaneously display the single point value and a graphical representation of the continuous glucose sensor data.

16. The system of claim 1, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to selectively display the single point value and the continuous glucose sensor data responsive to user interaction.

17. The system of claim 1, wherein the receiver unit comprises a processor module configured to automatically receive the single point glucose sensor data without user interaction.

18. An integrated system comprising:

a continuous glucose sensor configured to continuously measure a glucose concentration in a host, wherein the continuous glucose sensor generates continuous glucose sensor data associated with the glucose concentration in the host;

a single point glucose monitor, wherein the single point monitor generates single point glucose sensor data associated with a glucose concentration of a biological sample received from the host; and

a receiver unit configured to automatically receive the single point glucose sensor data without user interaction, wherein the receiver unit is in data communication with the continuous glucose sensor and configured to receive and calibrate the continuous glucose sensor data using the single point glucose sensor data, and wherein the single point glucose monitor is physically connected to the receiver unit.

19. The system of claim 18, wherein the receiver unit is configured to automatically receive the single point glucose sensor data without user interaction.

20. The system of claim 18, wherein the receiver unit is in data communication with an insulin delivery device, and wherein the receiver unit is further configured to process and transmit insulin administration information to the insulin delivery device.

21. The system of claim 18, wherein each of the continuous glucose sensor and the single point glucose monitor comprise a sensing membrane comprising an enzyme domain, and wherein the enzyme domain of the sensing membrane of the continuous glucose sensor and the enzyme domain of the sensing membrane of the single point glucose monitor are substantially the same.

22. The system of claim 18, wherein the receiver unit is configured to calibrate the continuous sensor data using at least one single point value from the single point glucose sensor data.

23. The system of claim 18, wherein the single point glucose monitor is configured to receive a single use test strip.

24. The system of claim 18, wherein the receiver unit comprises programming to control time and/or amount of administration of insulin to the host.

25. The system of claim 18, wherein the receiver unit further comprises programming to calculate a rate of change of the continuous glucose data or a directional trend of the continuous glucose data.

26. The system of claim 25, wherein the programming to control time and/or amount of administration of insulin to the host comprises programming to control administration of insulin to the host based at least in part on the rate of change of the continuous glucose data or the directional trend of the continuous glucose data.

27. The system of claim 25, wherein the programming to control time and/or amount of administration of insulin to the host comprises programming to control administration of insulin to the host based at least in part on the glucose concentration.

28. The system of claim 18, further comprising an insulin pump, and wherein the data communication with the insulin delivery device comprises data communication with the insulin pump.

29. The system of claim 18, wherein the receiver unit is configured to monitor the continuous glucose sensor data to adaptively determine a time for requesting a biological sample.

30. The system of claim 18, wherein the receiver comprises a user interface, and wherein the receiver unit is configured to prompt the user, via the user interface, to provide a biological sample to the single point glucose monitor at predetermined intervals.

31. The system of claim 18, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to prompt the user to provide a biological sample to the single point glucose monitor based upon one or more events.

32. The system of claim 31, wherein the one or more events comprise one or more events selected from the group consisting of meals, exercise, large excursions in glucose levels, and faulty or interrupted data readings.

33. The system of claim 18, wherein receiver unit is configured to compare the single point glucose sensor data with one or more acceptability parameters.

34. The system of claim 18, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to display the single point glucose sensor data from the single point glucose monitor and the continuous glucose sensor data from the continuous glucose sensor on the user interface.

35. The system of claim 18, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to simultaneously display numeric single point glucose sensor data and a graphical representation of the continuous glucose sensor data.

36. The system of claim 18, wherein the receiver unit comprises a user interface, and wherein the receiver unit is configured to selectively display the single point glucose sensor data and the continuous glucose sensor data based on user interaction.