Norovirus Vaccine Formulations
First Claim
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1. A composition comprising at least one Norovirus antigen and at least one adjuvant.
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Abstract
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
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53 Claims
- 1. A composition comprising at least one Norovirus antigen and at least one adjuvant.
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48. A method of making Norovirus antigen formulations, comprising the steps of:
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(a) preparing a pre-lyophilization solution comprising Norovirus antigen, sucrose, and chitosan, wherein the mass ratio of sucrose to chitosan is from about 0;
1 to about 10;
1;(b) freezing said solution; and (c) lyophilizing the frozen solution for 30-72 hours, wherein the final lyophilized product contains a percentage of said Norovirus antigen in aggregated form. - View Dependent Claims (49, 50, 51, 52, 53)
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Specification