Substances for Reducing Occurence of Major Cardiac Events in Humans

• US 20080299187A1
• Filed: 06/01/2007
• Published: 12/04/2008
• Est. Priority Date: 06/01/2007
• Status: Abandoned Application

• Current Assignee: Nordic Naturals Incorporated
• Original Assignee: Nordic Naturals Incorporated
• Inventors: Opheim, Joar, MacKay, Douglas
• Application Number:
  US11/757,340
• Publication Number:
  US 20080299187A1
• Time in Patent Office: Days
• US Class Current: 424/452
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/341 not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• CPC Class Codes: A61K 31/351 not condensed with another ring
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 35/60 Fish, e.g. seahorses; Fish eggs
• CPC Class Codes: A61K 36/06 Fungi, e.g. yeasts
• CPC Class Codes: A61K 36/53 Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/88 Liliopsida (monocotyledons)
• CPC Class Codes: A61K 9/4875 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/4858
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A medicament comprising a dispersion of Red Yeast Rice extract in Omega-3 Oils. The medicament is supplied in capsules such that a daily dose is dispensed in an integral number of capsules. A dispersant is used, preferably Lysine and bamboo. The ratio of Red Yeast Rice Extract to EPA+DHA is in the range between about 1.4 and 2.8. The medicament reduces cholesterol, triglycerides, and reduces serious heart incidents.

Claims

1. A medicament comprising red yeast rice extract dispersed in fish oil

2. The medicament of claim 1, wherein the fish oil comprises at least 60% of Omega-3 oils.

3. The medicament of claim 2, wherein said red yeast rice extract comprises at least 0.1% monacolin K.

4. The medicament of claim 2, wherein said red yeast rice extract comprises at least 0.2% monacolin K and at least 0.4% total monacolins.

5. The medicament of claim 2, wherein the fish oil comprises 70% of Omega-3 oils.

6. The medicament of claim 5, wherein the Omega-3 oils comprise 50% EPA and 35% DHA.

7. The medicament of claim 5, wherein the Omega-3 oils comprise 69% EPA and 16% DHA.

8. The medicament of claim 5, wherein the weight ratio of fish oil to red yeast rice extract is in the range between about 1.4 to 2.8.

9. The medicament of claim 8, further comprising a dispersing agent.

10. The medicament of claim 9, wherein the dispersant comprises 3% Lysine and 2% Bamboo.

11. The medicament of claim 9, further comprising a soft gelatin capsule into which the fish oil, red yeast rice extract and dispersing agent are loaded.

12. The medicament of claim 11, wherein a daily dose of the medicament is delivered by an integral number of capsules.

13. The medicament of claim 12, wherein the daily dose of medicament comprises about 1000 mg. of EPA plus DHA and 1200 mg of Red Yeast Rice extract.

14. The medicament of claim 12, wherein the daily dose of medicament comprises about 2000 mg. of EPA plus DHA and 1200 mg of Red Yeast Rice extract.

15. The medicament of claim 12, wherein the daily dose of medicament comprises about 2000 mg. of EPA plus DHA and 2400 mg of Red Yeast Rice extract.

16. The medicament of claim 12, wherein the daily dose of medicament comprises about 4000 mg. of EPA plus DHA and 2400 mg of Red Yeast Rice extract.

17. The medicament of claim 11, further comprising an antioxidant.

18. The medicament of claim 11, wherein the antioxidant is chosen from the group consisting of Rosemary, vitamin E, astaxanthine, carnitine, ascorbyl palmitate, tocopherols.

19. A method of reducing serum cholesterol and triglycerides in humans comprising administering a daily dosage comprising EPA, DHA, and Red Yeast Rice extract delivered in an integral number of gelatin capsules.

20. The method of claim 19, wherein a daily dosage comprises about 4000 mg. of EPA plus DHA and 2400 mg. of Red Yeast Rice extract.

21. The method of claim 19, wherein a daily dosage comprises about 1000 mg. of EPA plus DHA and 1200 mg. of Red Yeast Rice extract.

22. The method of claim 19, wherein a daily dosage comprises about 2000 mg. of EPA plus DHA and 1200 mg. of Red Yeast Rice extract.

23. The method of claim 19, wherein a daily dosage comprises about 2000 mg. of EPA plus DHA and 2400 mg. of Red Yeast Rice extract.