NEAR-INFRARED DYES AS SURFACE ENHANCED RAMAN SCATTERING REPORTERS
First Claim
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1. A nanoparticle comprising a SERS-active reporter molecule of the formula:
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A-Ywherein;
A is selected from the group consisting of;
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Abstract
Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is selected from the group consisting of:
wherein X1 is CR4 or N; and Y is selected from the group consisting of:
58 Citations
48 Claims
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1. A nanoparticle comprising a SERS-active reporter molecule of the formula:
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A-Ywherein; A is selected from the group consisting of; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14)
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13. The nanoparticle of 12, wherein the glass comprises SiOx.
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15. A method for labeling a molecule, cell, bead, or solid support, the method comprising:
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(a) providing at least one of a molecule, cell, bead, or solid support; and (b) attaching a particle to the at least one of a molecule, cell, bead, or solid support, wherein the particle comprises a surface-enhanced Raman spectroscopy (SERS)-active nanoparticle having associated therewith a dye of Formula;
A-Ywherein; A is selected from the group consisting of; - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for detecting the presence or amount of one or more analytes in a biological sample, the method comprising:
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(a) providing a biological sample suspected of containing one or more analytes; (b) contacting the biological sample with a reagent comprising one or more SERS-active nanoparticles having associated therewith at least one specific binding member having an affinity for the one or more analytes and at least one SERS-active reporter molecule of Formula;
A-Ywherein; A is selected from the group consisting of; - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A kit comprising a reagent comprising one or more surface-enhanced Raman spectroscopy (SERS)-active nanoparticles having associated therewith at least one SERS-active reporter molecule of Formula:
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A-Ywherein; A is selected from the group consisting of; - View Dependent Claims (46, 47, 48)
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Specification