CALCULATION DEVICE FOR METABOLIC CONTROL OF CRITICALLY ILL AND/OR DIABETIC PATIENTS

• US 20080306353A1
• Filed: 10/09/2007
• Published: 12/11/2008
• Est. Priority Date: 11/03/2006
• Status: Abandoned Application

• Current Assignee: Intersection Lifesciences Limited, Mystic Medical Systems, LLC
• Original Assignee: Mystic Medical Systems, LLC
• Inventors: Douglas, Joel S., Chase, James Geoffrey, Hann, Christopher Eric, Lotz, Thomas Friedhelm, Shaw, Geoffrey Mark, Lin, Jessica, Lonergan, Timothy Rhys John, Le Compte, Aaron James
• Application Number:
  US11/869,322
• Publication Number:
  US 20080306353A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation

Abstract

A method of providing blood glucose therapy for a critically ill patient includes calculating a baseline nutrition feed requirement based on an algorithm that incorporates at least one of age, gender, and body size of the patient: determining a first blood glucose level; determining a second blood glucose level after a preselected time interval: determining a first body temperature reading: comparing the blood glucose levels: and administering either nutrition or insulin. The amount of nutrition administered to the patient is based on a first change in blood glucose level, the current body temperature reading, and a predetermined feed algorithm based on the second blood glucose level as well as the baseline nutritional feed requirement. The amount of insulin administered is based on a second change in blood glucose level, body temperature, and a predetermined insulin algorithm that incorporates at least one of the patient'"'"'s body frame size, age, and gender.

Claims

1. A method of providing a blood glucose therapy for a critically ill patient, said method comprising the steps of:

calculating a baseline nutritional feed requirement for said patient based on an algorithm that incorporates at least a weight of said patient;

determining a first body temperature of said patient;

determining a first blood glucose level of said patient;

determining at least a second body temperature of said patient after a preselected time period;

determining at least a second blood glucose level of said patient after a preselected time period; and

comparing said at least second blood glucose level to said first blood glucose level;

administering one of an amount of nutritional feed to said patient and an amount of insulin to said patient;

wherein said amount of nutritional feed administered to said patient is based on a first decrease in blood glucose level and a predetermined feed algorithm that incorporates said second blood glucose level and said patient'"'"'s baseline nutritional feed requirement; and

wherein said amount of insulin administered to said patient is based on a second decrease in blood glucose level that is less than said first decrease in blood glucose level and a predetermined insulin algorithm that incorporates said at least second blood glucose level and said patient'"'"'s weight.

2. The method of claim 1, wherein said step of administering one of an amount of nutritional feed to said patient and an amount of insulin to said patient comprises maintaining said blood glucose level of said patient in the range of 4.0 mmol/L to 7.75 mmol/L.

3. The method of claim 1, wherein said preselected time period is 2 hours or less.

4. The method of claim 1, wherein said method is used to reduce the occurrence of ventilator-induced pneumonia by controlling a patient'"'"'s blood glucose level.

5. The method of claim 1, wherein said patient was not diagnosed with diabetes prior to becoming critically ill and in which said patient is not otherwise considered to be either a type I or type II diabetic.

6. The method of claim 1, wherein said nutritional feed and said insulin administered to said patient is determined using a linear slide rule calculator or a circular slide rule calculator.

7. The method of claim 1, wherein said nutritional feed and said insulin administered to said patient is determined using an electronic computing device.

8. The method of claim 1, wherein blood glucose levels of said patient are determined repetitively.

9. The method of claim 1, wherein said predetermined feed algorithm incorporates said patient'"'"'s one or more metabolic markers selected from the group of body temperature, renal function, urine output, catecholamine dosage, blood pressure and one or more patient status variables selected from the group consisting of age, weight and height, gender, and body frame size.

10. The method of claim 1, wherein said step of administering one of an amount of nutritional feed to said patient and an amount of insulin to said patient is effected using a pump.

11. A method of determining a nutritional input and an insulin input for a discrete time period for a patient that is critically ill, said method comprising the steps of:

determining an insulin scaling factor;

determining a nutrition scaling factor;

determining a precursor of a metabolic state of said patient based on a selected metabolic marker;

determining a blood glucose level of said patient;

entering data indicative of said insulin scaling factor, said nutrition scaling factor, said precursor of a metabolic state of said patient, and said blood glucose level of said patient into an electronic calculation means;

calculating one of an insulin amount to be administered to said patient and a nutrition amount to be administered to said patient;

wherein said insulin amount is based on said entered information and wherein said nutrition amount is based on said entered information.

12. The method of claim 11, wherein said selected metabolic marker of said patient is selected from the group consisting of body temperature, renal function, urine output, blood pressure, catecholamine dosage, age, weight, height, gender, and combinations of the foregoing.

13. The method of claim 11, wherein said patient is at least one of diabetic or stress-induced hyperglycemic.

14. A digital computational device for assisting a clinician in determining a therapy for a patient, said device comprising:

means for calculating a recommended nutrition rate from a first corresponding algorithm, said first corresponding algorithm comprising calculating a first value from one or more physiological parameters specific to said patient and one or more real-time precursor status indicators; and

means for calculating a recommended insulin dosage from a second corresponding algorithm, said second corresponding algorithm comprising calculating a second value from one or more physiological parameters specific to said patient and one or more real-time precursor status indicators;

wherein said calculated recommended nutrition rate and said calculated recommended insulin dosage are incorporated into said therapy for obtaining and maintaining metabolic homeostasis in said patient.

15. The device of claim 14, wherein said one or more physiological parameters and said one or more real-time precursor status indicators are input as digitized data.

16. The device of claim 14, wherein said one or more physiological parameters specific to said patient corresponds to at least one of said patient'"'"'s age, gender, height and weight, body temperature, previous nutrition dosage, previous insulin dosage, and current blood glucose level.

17. The device of claim 14, wherein said one or more real-time precursor status indicators includes scaling factors indicative of values selected from the group consisting of body temperature, renal function, urine output, blood pressure, medication history, previous nutrition dosage, previous insulin dosage, current blood glucose level, and combinations of the foregoing.

18. A method of establishing metabolic homeostasis in a patient having hyperglycemic blood glucose levels, said method comprising the steps of:

inputting a first physiological parameter into an electronic calculation device, said first physiological parameter comprising a factor specific to said patient;

inputting a second physiological parameter into said electronic calculation device, said second physiological parameter comprising a real-time parameter comprising a factor indicative of said patient'"'"'s metabolism;

inputting a third physiological parameter into said electronic calculation device, said third physiological parameter comprising at least one factor derived from current and past data relating to said patient; and

calculating a recommended dosing rate to be administered to said patient from said input parameters.

19. The method of claim 18, further comprising controlling said patient'"'"'s blood glucose level to reduce the occurrence of ventilator-induced pneumonia in said patient.

20. The method of claim 18, further comprising providing a confirmation signal of said calculated recommended dosing rate to said electronic calculation device and communicating said calculated recommended dosing rate to a pump for infusion into a patient.

21. A method of using a digital computational device to establish metabolic homeostasis in a patient having a hyperglycemic blood glucose level, said method comprising:

inputting information specific to said patient into said digital computational device, said information being indicative of at least one of the age, gender, and body size of said patient;

inputting a physiological parameter into said digital computational device, said physiological parameter comprising a real-time parameter comprising a factor indicative of said patient'"'"'s metabolism;

inputting a blood glucose value of said patient and prior nutrition and insulin dosages delivered to said patient relating to a discrete time period into said digital computational device; and

calculating a recommended dosing rate to be administered to said patient, said recommended dosing rate being calculated from said input information specific to said patient, said input physiological parameter, and said input blood glucose value and said prior nutrition and insulin dosages.

22. The method of claim 21, further comprising receiving a confirmatory signal from said electronic device, said confirmatory signal confirming said recommended dosing rate.

23. The method of claim 21, further comprising communicating said recommended dosing rate to a pump configured to infuse said patient with one of insulin and nutrition.

24. The method of claim 21, wherein said step of inputting a physiological parameter into said digital computational device comprises reading a body temperature of said patient via a device connected to said digital computational device.

25. The method of claim 21, wherein said step of inputting a blood glucose value into said digital computational device comprises reading said blood glucose value of said patient via a device connected to said digital computational device.