• US 20080306368A1
  • Filed: 08/21/2008
  • Published: 12/11/2008
  • Est. Priority Date: 08/01/2003
  • Status: Active Grant
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First Claim
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1. A method for calibrating a substantially continuous analyte sensor, the method comprising:

  • receiving a data stream from an analyte sensor, including one or more sensor data points;

    receiving reference data from a reference analyte monitor, comprising one or more reference data points;

    providing at least one matched data pair by matching reference analyte data to substantially time corresponding sensor data;

    creating a conversion function based on said at least one matched data pair;

    evaluating said at least one matched data pair, including ensuring said at least one matched data pair is substantially distributed with additional matched data pairs, if present, between high and low matched data pairs over a predetermined time range, wherein the step of evaluating said at least one matched data pair further comprises at least one of evaluating a rate of change of the analyte concentration, evaluating a congruence of respective sensor and reference data in a matched data pair, and evaluating physiological changes; and

    subsequently modifying said conversion function if such modification is required by said evaluation.

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