INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR

• US 20080306435A1
• Filed: 06/05/2008
• Published: 12/11/2008
• Est. Priority Date: 06/08/2007
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Kamath, Apurv U., Yang, Richard C., Leach, Jacob S., Quintana, Nelson
• Granted Patent: US 8,562,558 B2
• Time in Patent Office: Days
• US Class Current: 604/66
• CPC Class Codes: A61B 2560/0406 specially shaped apparatus housings
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2209/086 Docking stations
• CPC Class Codes: A61M 5/003 Kits for diabetics
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: G06T 11/206 Drawing of charts or graphs

Abstract

An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.

Claims

1. An integrated system for monitoring and treating diabetes, the system comprising:

a receiver configured and arranged to receive continuous glucose sensor data from a continuous glucose sensor;

a processor module configured to process the continuous glucose sensor data and to provide first and second medicament dosing information based at least in part on the continuous glucose sensor data; and

a communication module configured and arranged to communicate the medicament dosing information with a first integrated medicament delivery device and a second integrated medicament delivery device.

2. The integrated system of claim 1, wherein the first medicament dosing information comprises a basal medicament dose and the first integrated medicament delivery device comprises a basal medicament delivery device.

3. The integrated system of claim 2, wherein the basal medicament delivery device comprises a medicament pump configured to infuse a first medicament.

4. The integrated system of claim 2, wherein the processor module comprises programming to calculate a basal dose based at least in part on the continuous glucose sensor data.

5. The integrated system of claim 2, wherein the second medicament dosing information comprises a bolus medicament dose and the second integrated medicament delivery device comprises a bolus medicament delivery device.

6. The integrated system of claim 5, wherein the processor module comprises programming to calculate a bolus dose based at least in part on the continuous glucose sensor data.

7. The integrated system of claim 5, wherein the bolus medicament delivery device comprises a hand-held medicament injection pen configured to infuse a second medicament.

8. The integrated system of claim 5, wherein the bolus medicament delivery device comprises a motor configured to automatically set the amount of medicament and the medicament dosing information comprises an instruction for the medicament delivery device to automatically portion out the bolus dose, whereby the portioned out bolus dose can be manually delivered by the host.

9. The integrated system of claim 5, wherein the bolus medicament delivery device comprises a motor to control a rate of medicament injection into the host.

10. The integrated system of claim 1, further comprising a user interface configured and arranged to display at least one of continuous glucose sensor data and medicament dosing information.

11. The integrated system of claim 10, wherein the user interface is further configured for input of at least one of host information and medicament delivery device information.

12. The integrated system of claim 11, wherein the host information comprises at least one of host identity, host physical state, target glucose concentration and type of medicament to be delivered.

13. The integrated system of claim 11, wherein the medicament delivery information comprises at least one of host identity, identification of a functionally connected medicament delivery device, a type of medicament to be delivered, a medicament delivery profile, a medicament delivery protocol, and a failsafe.

14. The integrated system of claim 1, wherein the communication module comprises a communication module configured and arranged to interrogate and/or provide medicament dosing information to the first medicament delivery device and the second medicament delivery device.

15. The integrated system of claim 1, wherein the receiver comprises the communication module and the processor module, and wherein the receiver wirelessly communicates with the first and second medicament delivery devices.

16. The integrated system of claim 1, wherein the receiver comprises the communication module and the processor module, and wherein the receiver is physically connected to at least one of the first medicament delivery device and the second medicament delivery device.

17. A method of self-monitoring and self-treating diabetes, the method comprising:

receiving continuous glucose sensor data from an operably connected continuous glucose sensor;

processing the continuous glucose sensor data;

calculating medicament dosing information for at least two integrated medicament delivery devices based at least in part on the continuous glucose sensor data; and

communicating the medicament dosing information with the integrated medicament delivery devices.

18. The method of claim 17, wherein the step of calculating medicament dosing information comprises calculating a basal dose based at least in part on the continuous glucose sensor data.

19. The method of claim 18, wherein the step of communicating comprises communicating the basal medicament dose to a medicament pump.

20. The method of claim 19, further comprising infusing the basal medicament dose.

21. The method of claim 17, wherein the step of providing medicament dosing information comprises calculating a bolus dose based at least in part on the continuous glucose sensor data.

22. The method of claim 21, wherein the step of communicating comprises communicating the bolus medicament dose to a hand-held injector pen.

23. The method of claim 22, wherein the step of delivering comprises injecting the bolus medicament dose.

24. The method of claim 23, wherein the step of communicating the bolus dose further comprises providing an instruction to automatically set at least one of the amount of medicament and rate of delivery based at least in part on the medicament dosing information.

25. The method of claim 24, wherein the step of delivering the bolus dose further comprises automatically setting the amount of medicament based at least in part on the provided instruction.

26. The method of claim 24, wherein the step of delivering the bolus dose further comprises automatically setting the rate of delivery based at least in part on the provided instruction.

27. The method of claim 17, further comprising displaying at least one of continuous glucose sensor data and medicament dosing information.

28. The method of claim 17, further comprising inputting at least one of host information and medicament delivery device information.

29. The method of claim 17, wherein the step of communicating comprises wirelessly communicating.

30. The method of claim 29, wherein the step of wirelessly communicating comprises interrogating and/or providing medicament dosing information.