TITRATION DOSING REGIMEN FOR CONTROLLED RELEASE TRAMADOL
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Abstract
A titration dosing regimen for the administration of controlled release tramadol analgesic to patients. The titration dosing regimen provides a significant reduction in the occurrence of adverse effects from the introduction of controlled released tramadol dosing, thus increasing patient compliance and medication tolerability.
141 Citations
30 Claims
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1-8. -8. (canceled)
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9. A dosage regimen for administering tramadol to a patient comprising administering:
- about 100 mg of tramadol in a controlled release dosage form once-a-day on days 1 through 7;
then about 200 mg of tramadol in a controlled release dosage form once-a-day on days 8 through 14;
then about 300 mg of tramadol in a controlled release dosage form once-a-day on day 15 and optionally thereafter. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
- about 100 mg of tramadol in a controlled release dosage form once-a-day on days 1 through 7;
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17. A dosage regimen for administering tramadol to a patient comprising administering:
- about 175 mg to about 225 mg of tramadol in a controlled release dosage form once-a-day for about 4 to about 10 days;
then about 275 mg to about 325 mg of tramadol in a controlled release dosage form once-a-day for at least 1 day and optionally thereafter. - View Dependent Claims (18, 19, 21)
- about 175 mg to about 225 mg of tramadol in a controlled release dosage form once-a-day for about 4 to about 10 days;
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20. The dosage regimen of claim 20 wherein each oral dosage form provides an in vitro release of tramadol hydrochloride of about 24 hours or more.
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22. A dosage regimen for administering tramadol to a patient comprising administering:
- about 200 mg of tramadol in a controlled release dosage form once-a-day for days 1 through 7;
then about 300 mg of tramadol in a controlled release dosage form once-a-day for at least 1 day and optionally thereafter. - View Dependent Claims (23, 24, 25, 26)
- about 200 mg of tramadol in a controlled release dosage form once-a-day for days 1 through 7;
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27. A kit for the administration of a dosage regimen of tramadol comprising:
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instructions to administer the following amounts of tramadol in controlled release oral dosage forms according to the following dosage regimen; 100 mg of tramadol once-a-day on days 1 through 7; 200 mg of tramadol once-a-day on about days 8 through 14; and 300 mg of tramadol once-a-day on about days 15 through 21, and optionally thereafter; and a sufficient quantity of controlled release oral dosage forms of tramadol to administer tramadol according to the dosage regimen. - View Dependent Claims (28)
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29. A kit for the administration of a dosage regimen of tramadol comprising:
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instructions to administer the following amounts of tramadol in controlled release oral dosage forms according to the following dosage regimen; 200 mg of tramadol once-a-day on days 1 through 7; and 300 mg of tramadol once-a-day on about days 8 through 14, and optionally thereafter; and a sufficient quantity of controlled release oral dosage forms of tramadol to administer tramadol according to the dosage regimen. - View Dependent Claims (30)
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Specification