APPLICATION OF D-PSICOSE TO SUPPRESSION OF ABNORMAL CIRCADIAN INCREASE IN BLOOD GLUCOSE LEVEL

• US 20090062215A1
• Filed: 03/22/2006
• Published: 03/05/2009
• Est. Priority Date: 03/23/2005
• Status: Active Grant

• Current Assignee: Matsutani Chemical industry Co,. Ltd.
• Original Assignee: Rare Sugar Production Technical Research Laboratories, LLC
• Inventors: Matsuo, Tatsuhiro, Takekawa, Kaoru, Morimoto, Kenji, Izumori, Ken, Tokuda, Masaaki
• Granted Patent: US 8,071,558 B2
• Time in Patent Office: Days
• US Class Current: 514/25
• CPC Class Codes: A23K 20/163 Sugars; Polysaccharides
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A23L 27/30 Artificial sweetening agents
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A61K 31/7004 Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

Claims

1. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration, which contains D-psicose as the active component and is used for suppressing daily blood glucose level at a low level by suppressing a rapid increase of blood glucose concentration with D-glucose composing digestive sugars ingested from foods and drinks.

2. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 1, where D-psicose is D-psicose and/or a derivative thereof.

3. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 1, where D-psicose is a mixture of D-psicose and D-fructose.

4. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 3, where the mixture is a crystalline mixture.

5. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 1, where D-psicose and/or a derivative thereof is blended in the composition to a content of 0.1 to 50% by weight.

6. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 1, where the composition is in a form selected from the group consisting of sweeteners, seasonings, food additives, food materials, health food and drink products, pharmaceutical products and feeds containing the composition in blend with D-psicose and/or a derivative thereof as the active component.

7. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 6, where the composition is in a form selected from the group consisting of sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds containing the composition in blend with D-psicose and/or a derivative thereof as the active component, for use in preventing or therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and diseases of which the symptoms can be ameliorated or the onset can be prevented via the suppression of the abnormal intra-day increase of plasma glucose concentration (blood glucose level), such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and arteriosclerosis.

8. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 6, where D-psicose and/or a derivative thereof is blended in a food containing carbohydrates and/or sugars to a content of 0.1 to 50% by weight of the total carbohydrate amount (total sugar amount) in the food.

9. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 6, where D-psicose and/or a derivative thereof is blended in a drinkable liquid such as water to a content of 0.1 to 50% by weight.

10. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 6, where D-psicose and/or a derivative thereof is blended in a feed containing carbohydrates and/or sugars to a content of 0.1 to 50% by weight of the total carbohydrate amount (total sugar amount) in the feed.

11. A composition for suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 6, where the health food and drink products are food and drink products for diets or diabetic diets.

12. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day by suppressing a rapid increase of blood glucose level with D-glucose composing digestive sugars ingested from foods and drinks.

13. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration according to claim 12, where the action of D-psicose to suppress the abnormal intra-day increase of plasma glucose concentration is based on enhancing the uptake of blood glucose into liver and muscle, and/or inhibiting sugar digestive enzymes in the gastrointestinal tract, and/or inhibiting sugar absorption from the gastrointestinal tract, and/or stimulating insulin secretion from pancreas.

14. A method for using D-psicose according to claim 12, where D-psicose is D-psicose and/or a derivative thereof, and/or is in a form of a composition in blend with D-psicose and/or a derivative thereof.

15. A method for using D-psicose according to claim 12, where D-psicose and/or a derivative thereof is blended in the composition to a content of 0.1 to 50% by weight.

16. A method for using D-psicose according to claim 15, where D-psicose and/or a derivative thereof is blended in a food containing carbohydrates and/or sugars to a content of 0.1 to 50% by weight of the total carbohydrate amount (total sugar amount) in the food.

17. A method for using D-psicose according to claim 15, where D-psicose and/or a derivative thereof is blended in a drinkable liquid such as water to a content of 0.1 to 50% by weight.

18. A method for using D-psicose according to claim 15, where D-psicose and/or a derivative thereof is blended in a feed containing carbohydrates and/or sugars to a content of 0.1 to 50% by weight of the total carbohydrate amount (total sugar amount) in the feed.